Metal-Free Aryltrifluoromethylation of Activated Alkenes

被引：285
|
作者：
Kong, Wangqing [1 ]
Casimiro, Maria [1 ]
Fuentes, Noelia [1 ]
Merino, Estibaliz [1 ]
Nevado, Cristina [1 ]
机构：
[1] Univ Zurich, Inst Organ Chem, CH-8006 Zurich, Switzerland
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 49期
基金：
欧洲研究理事会;
关键词：
alkenes; arenes; iodine; Togni reagent; trifluoromethylation; COPPER-CATALYZED TRIFLUOROMETHYLATION; BOND FORMATION; ELECTROPHILIC TRIFLUOROMETHYLATION; FLUORINATION; OXINDOLES; ALCOHOLS; IODIDES; REAGENT; SULFUR;
D O I：
10.1002/anie.201307377
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Metal-free: The first metal-free aryltrifluoromethylation of activated alkenes has been developed. With this method, trifluoromethylated isoquinolinediones, spirobicycles, oxindoles, and α-aryl-β- trifluoromethylamides were obtained with high control of the regioselectivity. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：13086 / 13090
页数：5
相关论文
共 50 条
  • [1] Transition Metal-Free Reduction of Activated Alkenes Using a Living Microorganism
    Brewster, Richard C.
    Suitor, Jack T.
    Bennett, Adam W.
    Wallace, Stephen
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2019, 58 (36) : 12409 - 12414
  • [2] Metal-free TBAI-catalyzed arylsulfonylation of activated alkenes with sulfonylhydrazides
    Yu, Wubin
    Hu, Peizhu
    Fan, Yuanyuan
    Yu, Congyao
    Yan, Xinhuan
    Li, Xiaoqing
    Xu, Xiangsheng
    ORGANIC & BIOMOLECULAR CHEMISTRY, 2015, 13 (11) : 3308 - 3313
  • [3] Metal-free aminofluorination and diamination of alkenes
    Liskin, Dmitry V.
    Michael, Forrest E.
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2012, 243
  • [4] Metal-Free Electrocatalytic Diacetoxylation of Alkenes
    Vanhoof, Jef R.
    De Smedt, Pieter J.
    Derhaeg, Jan
    Ameloot, Rob
    De Vos, Dirk E.
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2023, 62 (49)
  • [5] Metal-free intermolecular chloroamination of alkenes
    Ralston, Megan
    Davidson, Darcy
    Carney, Jeffrey
    Liskin, Dmitry
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2017, 254
  • [6] Metal-Free Aziridination of Alkenes with Free Amines by Thianthrenation
    Liu, Ming -Shang
    Shu, Wei
    ORGANIC SYNTHESES, 2024, 101 : 34 - 50
  • [7] Metal-free syn-dihydroxylation of alkenes
    Picon, Sylvain
    Tomkinson, Nicholas C. O.
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2010, 240
  • [8] Metal-free amination of alkenes based on maleimides
    Shen, Li-Wen
    Lei, Shuang-Ling
    Wang, Hong-Yan
    Wang, Xin
    Lu, Lin-Mu
    Wang, Guang-Wei
    Jia, Yun-Qing
    Xiang, Min
    ORGANIC & BIOMOLECULAR CHEMISTRY, 2025,
  • [9] Metal-Free Highly Regioselective Aminotrifluoroacetoxylation of Alkenes
    Lovick, Helena M.
    Michael, Forrest E.
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2010, 132 (04) : 1249 - +
  • [10] Metal-free intermolecular aminochlorination of unactivated alkenes
    Zhu, Nengbo
    Li, Yajun
    Bao, Hongli
    ORGANIC CHEMISTRY FRONTIERS, 2018, 5 (08): : 1303 - 1307
12345