Synthesis and characterization of curdlan/β-cyclodextrin composite hydrogels for sustained-release

被引：9

作者：

Li, Yucheng ^{[1
]}

Chen, Meiling ^{[1
]}

机构：

[1] Jiangnan Univ, Sch Chem & Mat Engn, Minist Educ, Key Lab Food Colloids & Biotechnol, Wuxi, Peoples R China

来源：

INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS | 2019年 / 68卷 / 13期

关键词：

Curdlan; beta-cyclodextrin; composite hydrogel; sustained-release; BETA-CYCLODEXTRIN; PACKING ANALYSIS; CROSS-LINKING; CELLULOSE; GEL; POLYSACCHARIDES;

D O I：

10.1080/00914037.2018.1506983

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Curdlan/beta-cyclodextrin (beta-CD) composite hydrogels were prepared by using epichlorohydrin (ECH) and ethylene glycol diglycidyl ether (EGDGE) as cross-linkers respectively. The results showed that a macromolecular network structure was formed. This composite hydrogels showed certain temperature sensitivity, regular swelling ratio and unique mechanical property. The addition of beta-CD improved the swelling property of hydrogels in neutral aqueous solution, showing completely opposite results to the cellulose/beta-CD hydrogels. This composite hydrogel had certain temperature sensitivity and could sustained-release sodium salicylate for more than 8 hours. The curdlan/beta-CD hydrogels, which were cross-linked by natural polymers, had a unique application prospect in the medicine.

引用

页码：778 / 787

页数：10

共 41 条

[1] Cellulose-based hydrogels: Present status and application prospects [J].

Chang, Chunyu ;

Zhang, Lina .

CARBOHYDRATE POLYMERS, 2011, 84 (01) :40-53

[2] PACKING ANALYSIS OF CARBOHYDRATES AND POLYSACCHARIDES .14. TRIPLE-HELICAL CRYSTALLINE-STRUCTURE OF CURDLAN AND PARAMYLON HYDRATES [J].

CHUAH, CT ;

SARKO, A ;

DESLANDES, Y ;

MARCHESSAULT, RH .

MACROMOLECULES, 1983, 16 (08) :1375-1382

[3] Physically and chemically cross-linked cellulose cryogels: Structure, properties and application for controlled release [J].

Ciolacu, Diana ;

Rudaz, Cyrielle ;

Vasilescu, Mihai ;

Budtova, Tatiana .

CARBOHYDRATE POLYMERS, 2016, 151 :392-400

[4]

Dae S. L., 2017, PROG ORG COAT, V111, P107, DOI [10.1016/j.porgcoat.2017.04.039, DOI 10.1016/J.PORGCOAT.2017.04.039]

[5] Preparation, characterization, and drug release properties of poly(2-hydroxyethyl methacrylate) hydrogels having β-cyclodextrin functionality [J].

Demir, Serap ;

Kahraman, M. Vezir ;

Bora, Nil ;

Apohan, Nilhan Kayaman ;

Ogan, Ayse .

JOURNAL OF APPLIED POLYMER SCIENCE, 2008, 109 (02) :1360-1368

[6] PACKING ANALYSIS OF CARBOHYDRATES AND POLYSACCHARIDES .13. TRIPLE-HELICAL STRUCTURE OF (1-]3)-BETA-D-GLUCAN [J].

DESLANDES, Y ;

MARCHESSAULT, RH ;

SARKO, A .

MACROMOLECULES, 1980, 13 (06) :1466-1471

[7] Soft, tough, and flexible curdlan hydrogels and organogels fabricated by covalent cross-linking [J].

Enomoto-Rogers, Yukiko ;

Kimura, Satoshi ;

Iwata, Tadahisa .

POLYMER, 2016, 100 :143-148

[8] INCLUSION OF AROMATIC-COMPOUNDS BY A BETA-CYCLODEXTRIN-EPICHLOROHYDRIN POLYMER [J].

HARADA, A ;

FURUE, M ;

NOZAKURA, S .

POLYMER JOURNAL, 1981, 13 (08) :777-781

[9] CURDLAN - A BACTERIAL GEL-FORMING BETA-1 3-GLUCAN [J].

HARADA, T ;

MISAKI, A ;

SAITO, H .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1968, 124 (1-3) :292-&

[10] PRODUCTION OF A FIRM RESILIENT GEL-FORMING POLYSACCHARIDE BY A MUTANT OF ALCALIGENES FAECALIS VAR MYXOGENES 10C3 [J].

HARADA, T ;

MASADA, M ;

FUJIMORI, K ;

MAEDA, I .

AGRICULTURAL AND BIOLOGICAL CHEMISTRY, 1966, 30 (02) :196-&

← 1 2 3 4 5 →