Serum-Based DNA Methylation Biomarkers in Colorectal Cancer: Potential for Screening and Early Detection

被引:35
作者
Summers, Thomas [1 ]
Langan, Russell C. [2 ]
Nissan, Aviram [3 ,4 ,5 ]
Bruecher, Bjoern L. D. M. [4 ,5 ]
Bilchik, Anton J. [4 ,5 ,6 ,7 ]
Protic, Mladjan [4 ,5 ,8 ,9 ]
Daumer, Martin [5 ,10 ]
Avital, Itzhak [4 ,5 ,11 ,12 ]
Stojadinovic, Alexander [1 ,4 ,5 ,12 ]
机构
[1] Walter Reed Natl Mil Med Ctr, Dept Pathol & Lab Serv, Bethesda, MD 20889 USA
[2] Georgetown Univ Hosp, Washington, DC 20007 USA
[3] Beilinson Med Ctr, Rabin Med Ctr, Div Surg Oncol, Dept Surg, Petah Tiqwa, Israel
[4] United States Mil Canc Inst, Washington, DC USA
[5] Theodor Billroth Acad, Int Consortium Res Excellence INCORE, Munich, Germany
[6] Calif Oncol Res Inst, Santa Monica, CA USA
[7] John Wayne Canc Inst, Santa Monica, CA USA
[8] Clin Ctr Vojvodina, Clin Abdominal Endocrine & Transplantat Surg, Novi Sad, Serbia
[9] Univ Novi Sad, Fac Med, Novi Sad 21000, Serbia
[10] Sylvia Lawry Ctr MS Res, Munich, Germany
[11] Uniformed Serv Univ Hlth Sci, Dept Surg, Bethesda, MD 20814 USA
[12] Bon Secours Canc Inst, Richmond, VA USA
关键词
Colorectal cancer; Biomarker: Early detection; Screening; Serum; DNA methylation; FREE PLASMA DNA; PANCREATIC-CANCER; MARKERS; MORTALITY; PATTERNS; THERAPY;
D O I
10.7150/jca.5839
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Colorectal cancer (CRC) is the third most common cause of cancer-related death in the United States. Early identification and treatment of pre-cancerous colorectal lesions, or node-negative CRC are highly effective interventions that substantially reduce disease-specific mortality. Colonoscopy remains a highly effective primary screening tool based on its excellent diagnostic accuracy, and its ability to remove pre-cancerous lesions. However, the nature of the procedure limits compliance with colonoscopy intended for population-based CRC screening. A significant advance in the screening and care of these patients could be realized by blood-based biomarkers, which could accurately identify patients at-risk for CRC development whom might benefit from early and/or more frequent surveillance for disease. We reviewed and herein discuss the potential for serum based DNA methylation biomarkers for screening and early detection of CRC.
引用
收藏
页码:210 / 216
页数:7
相关论文
共 26 条
[1]   Reduced Lung-Cancer Mortality with Low-Dose Computed Tomographic Screening [J].
Aberle, Denise R. ;
Adams, Amanda M. ;
Berg, Christine D. ;
Black, William C. ;
Clapp, Jonathan D. ;
Fagerstrom, Richard M. ;
Gareen, Ilana F. ;
Gatsonis, Constantine ;
Marcus, Pamela M. ;
Sicks, JoRean D. .
NEW ENGLAND JOURNAL OF MEDICINE, 2011, 365 (05) :395-409
[2]   Cell-free plasma DNA and purine nucleotide degradation markers following weightlifting exercise [J].
Atamaniuk, Johanna ;
Vidotto, Claudia ;
Kinzlbauer, Markus ;
Bachl, Norbert ;
Tiran, Beate ;
Tschan, Harald .
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY, 2010, 110 (04) :695-701
[3]   DNA methylation patterns and epigenetic memory [J].
Bird, A .
GENES & DEVELOPMENT, 2002, 16 (01) :6-21
[4]   Translational genomics: The challenge of developing cancer biomarkers [J].
Brooks, James D. .
GENOME RESEARCH, 2012, 22 (02) :183-187
[5]   Hypermethylation of hMLH1, HPP1, p14ARF, p16INK4A and APC in primary adenocarcinomas of the small bowel [J].
Bruecher, Bjoern L. D. M. ;
Geddert, Helene ;
Langner, Cord ;
Hoefler, Heinz ;
Fink, Ulrich ;
Siewert, Joerg R. ;
Sarbia, Mario .
INTERNATIONAL JOURNAL OF CANCER, 2006, 119 (06) :1298-1302
[6]   Considerations in the evaluation of surrogate endpoints in clinical trials: Summary of a National Institutes of Health Workshop [J].
De Gruttola, VG ;
Clax, P ;
DeMets, DL ;
Downing, GJ ;
Ellenberg, SS ;
Friedman, L ;
Gail, MH ;
Prentice, R ;
Wittes, J ;
Zeger, SL .
CONTROLLED CLINICAL TRIALS, 2001, 22 (05) :485-502
[7]   Are DNA methylation markers ready for colorectal cancer detection? [J].
De Paoli, Vania M. ;
Chen, Chun-Hao ;
Cheng, Yu-Wei .
CANCER BIOLOGY & THERAPY, 2010, 9 (11) :872-874
[8]   Cell-free DNA in human blood plasma: Length measurements in patients with pancreatic cancer and healthy controls [J].
Giacona, MB ;
Ruben, GC ;
Iczkowski, KA ;
Roos, TB ;
Porter, DM ;
Sorenson, GD .
PANCREAS, 1998, 17 (01) :89-97
[9]   Breast cancer incidence, 1980-2006: Combined roles of menopausal hormone therapy, screening mammography, and estrogen receptor status [J].
Glass, Andrew G. ;
Lacey, James V., Jr. ;
Carreon, Daniel ;
Hoover, Robert N. .
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2007, 99 (15) :1152-1161
[10]   Circulating nucleic acids in plasma or serum (CNAPS) as prognostic and predictive markers in patients with solid neoplasias [J].
Goebel, G ;
Zitt, M ;
Zitt, M ;
Müller, HM .
DISEASE MARKERS, 2005, 21 (03) :105-120