Preparation of monodisperse curcumin-imprinted polymer by precipitation polymerization and its application for the extraction of curcuminoids from Curcuma longa L.

被引：20

作者：

Kitabatake, Tomoko ^{[1
]}

Tabo, Hiromi ^{[1
]}

Matsunaga, Hisami ^{[1
]}

Haginaka, Jun ^{[1
]}

机构：

[1] Mukogawa Womens Univ, Sch Pharm & Pharmaceut Sci, Nishinomiya, Hyogo 6638179, Japan

来源：

ANALYTICAL AND BIOANALYTICAL CHEMISTRY | 2013年 / 405卷 / 20期

基金：

日本学术振兴会;

关键词：

Molecularly imprinted polymer; Precipitation polymerization; Curcumin; Demethoxycurcumin; Bisdemethoxycurcumin; SOLID-PHASE EXTRACTION; SELECTIVE EXTRACTION; BISPHENOL-A; WATER SAMPLES; MICROSPHERES; RECOGNITION; SEPARATION; MICROEXTRACTION; PLASMA; ONLINE;

D O I：

10.1007/s00216-013-7088-6

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A monodisperse molecularly imprinted polymer (MIP) for curcumin was first prepared by precipitation polymerization using methacrylamide (MAM) and 4-vinylpyridine as functional co-monomers, divinylbenzene as a crosslinker, and a mixture of acetonitrile and toluene as a porogen. The use of MAM as the co-monomer resulted in the formation of a monodisperse MIP and non-imprinted polymer (NIP). MIP and NIP, respectively, were monodispersed with a narrow particle size distribution (3.3 +/- 0.09 and 3.5 +/- 0.10 mu m). In addition to shape recognition, hydrophobic and hydrogen-bonding interactions affected the retention and molecular-recognition of curcumin on the MIP. The MIP for curcumin could extract curcuminoids (curcumin, demethoxycurcumin, and bisdemethoxycurcumin) in Curcuma longa L.

引用

页码：6555 / 6561

页数：7

共 32 条

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