Clean Synthesis of N-Pyrrolyl Azoles by Metal-Free Oxidative Cross-Coupling Using Recyclable Hypervalent Iodine Reagent

被引：11

作者：

Morimoto, Koji ^{[1
]}

Ogawa, Ryosuke ^{[1
]}

Koseki, Daichi ^{[1
]}

Takahashi, Yusuke ^{[1
]}

Dohi, Toshifumi ^{[1
]}

Kita, Yasuyuki ^{[1
]}

机构：

[1] Ritsumeikan Univ, Coll Pharmaceut Sci, Shiga 5258577, Japan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2015年 / 63卷 / 10期

基金：

日本学术振兴会;

关键词：

oxidative coupling; hypervalent iodine reagent; recycle; pyrrole; azole; C-N bond formation; H BOND FUNCTIONALIZATION; FLUOROUS ALKYL IODIDES; BIS(TRIFLUOROACETATE) ADDUCTS; CARBONYL-COMPOUNDS; IONIC LIQUID; C-N; REACTIVITY; ALCOHOLS; INDOLES; COPPER;

D O I：

10.1248/cpb.c15-00469

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The facile and clean oxidative coupling reaction of pyrroles with azoles has been achieved using the recyclable hypervalent iodine(III) reagents having adamantane structures. These iodine(III) reagents could be recovered from the reaction mixtures by a simple solid-liquid separation, i.e., filtration, for reuse.

引用

页码：819 / 824

页数：6

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