Advances in the Understanding of Mammalian Copper Transporters

被引：145

作者：

Wang, Yanfang ^{[1
,3
]}

Hodgkinson, Victoria ^{[1
,3
]}

Zhu, Sha ^{[1
,3
]}

Weisman, Gary A. ^{[1
,3
]}

Petris, Michael J. ^{[1
,2
,3
]}

机构：

[1] Univ Missouri, Dept Biochem, Columbia, MO 65211 USA

[2] Univ Missouri, Dept Nutr & Exercise Physiol, Columbia, MO 65211 USA

[3] Univ Missouri, Christopher S Bond Life Sci Ctr, Columbia, MO 65211 USA

来源：

ADVANCES IN NUTRITION | 2011年 / 2卷 / 02期

关键词：

D O I：

10.3945/an.110.000273

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Copper (Cu) is an essential micronutrient. Its ability to exist in 2 oxidation states (Cu1+ and Cu2+) allows it to function as an enzymatic cofactor in hydrolytic, electron transfer, and oxygen utilization reactions. Cu transporters CTR1, ATP7A, and ATP7B play key roles in ensuring that adequate Cu is available for Cu-requiring processes and the prevention of excess Cu accumulation within cells. Two diseases of Cu metabolism, Menkes disease and Wilson disease, which are caused by mutations in ATP7A and ATP7B, respectively, exemplify the critical importance of regulating Cu balance in humans. Herein, we review recent studies of the biochemical and cell biological characteristics of CTR1, ATP7A, and ATP7B, as well as emerging roles for Cu in new areas of physiology. Adv. Nutr. 2: 129-137, 2011.

引用

页码：129 / 137

页数：9

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