Direct Amination of Phenols under Metal-Free Conditions

被引：31

作者：

Yu, Jianzhong ^{[1
]}

Wang, Yongtao ^{[1
]}

Zhang, Peizhi ^{[2
]}

Wu, Jun ^{[1
]}

机构：

[1] Zhejiang Univ, Dept Chem, Hangzhou 310027, Zhejiang, Peoples R China

[2] Zhejiang Univ Sci & Technol, Sch Biol & Chem Engn, Hangzhou 310012, Zhejiang, Peoples R China

来源：

SYNLETT | 2013年 / 24卷 / 11期

基金：

中国国家自然科学基金;

关键词：

amination; phenols; metal-free; arylamines; carbazoles; CATALYZED ELECTROPHILIC AMINATION; N BOND FORMATION; C-H; ARYLBORONIC ACIDS; ARYL HALIDES; AMINO-ACID; COPPER; DERIVATIVES; REAGENTS;

D O I：

10.1055/s-0033-1338703

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Herein, we disclose the metal-free synthesis of arylamines via the direct amination of phenols using aminating reagents. This reaction procedure uses easy accessible aminating reagents and provides a versatile synthetic route to a broad range of arylamines with various functionalities in good to excellent yield. By using a two-step route of amination and oxidative coupling reaction, we synthesized three naturally occurring carbazole alkaloids: murrayafoline A, mukonine, and clausenine from two commercially available phenols.

引用

页码：1448 / 1454

页数：7

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