Direct Amination of Phenols under Metal-Free Conditions

被引：30
|
作者：
Yu, Jianzhong [1 ]
Wang, Yongtao [1 ]
Zhang, Peizhi [2 ]
Wu, Jun [1 ]
机构：
[1] Zhejiang Univ, Dept Chem, Hangzhou 310027, Zhejiang, Peoples R China
[2] Zhejiang Univ Sci & Technol, Sch Biol & Chem Engn, Hangzhou 310012, Zhejiang, Peoples R China
来源：
SYNLETT | 2013年 / 24卷 / 11期
基金：
中国国家自然科学基金;
关键词：
amination; phenols; metal-free; arylamines; carbazoles; CATALYZED ELECTROPHILIC AMINATION; N BOND FORMATION; C-H; ARYLBORONIC ACIDS; ARYL HALIDES; AMINO-ACID; COPPER; DERIVATIVES; REAGENTS;
D O I：
10.1055/s-0033-1338703
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Herein, we disclose the metal-free synthesis of arylamines via the direct amination of phenols using aminating reagents. This reaction procedure uses easy accessible aminating reagents and provides a versatile synthetic route to a broad range of arylamines with various functionalities in good to excellent yield. By using a two-step route of amination and oxidative coupling reaction, we synthesized three naturally occurring carbazole alkaloids: murrayafoline A, mukonine, and clausenine from two commercially available phenols.
引用
收藏
页码：1448 / 1454
页数：7
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