Multiple sclerosis and allied white matter diseases

被引：8

作者：

Filippi, Massimo ^{[1
]}

Rocca, Maria Assunta

机构：

[1] Inst Sci, Dept Neurol, Neuroimaging Res Unit, I-20132 Milan, Italy

来源：

NEUROLOGICAL SCIENCES | 2008年 / 29卷 / Suppl 3期

关键词：

Multiple sclerosis; White matter diseases; Proton magnetic resonance spectroscopy; Magnetization transfer MRI; Diffusion MRI; Functional MRI;

D O I：

10.1007/s10072-008-1007-1

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Advanced magnetic resonance imaging (MRI) approaches are extensively used for the assessment of central nervous system (CNS) damage in patients with multiple sclerosis (MS) and allied white matter diseases. Through their ability to obtain simultaneous measures of abnormalities of structure and function at a global and regional level, these techniques, which include magnetization transfer MRI, diffusion tensor MRI and proton MR spectroscopy, are contributing to filling the voids between clinical and MRI measures. As a consequence, they are dramatically improving our understanding of the mechanisms related to the accumulation of irreversible disability in these conditions. Future improvements, including the development of new sequences and post-processing methods as well as the use of high-field MRI, despite being a major technical challenge, hold new and exciting promise.

引用

页码：S319 / S322

页数：4

共 26 条

[1] In vivo assessment of cervical cord damage in MS patients: a longitudinal diffusion tensor MRI study [J].

Agosta, F. ;

Absinta, M. ;

Sormani, M. P. ;

Ghezzi, A. ;

Bertolotto, A. ;

Montanari, E. ;

Comi, G. ;

Filippi, M. .

BRAIN, 2007, 130 :2211-2219

[2] Tactile-associated recruitment of the cervical cord is altered in patients with multiple sclerosis [J].

Agosta, Federica ;

Valsasina, Paola ;

Caputo, Domenico ;

Stroman, Patrick W. ;

Filippi, Massimo .

NEUROIMAGE, 2008, 39 (04) :1542-1548

[3] Non-invasive mapping of connections between human thalamus and cortex using diffusion imaging [J].

Behrens, TEJ ;

Johansen-Berg, H ;

Woolrich, MW ;

Smith, SM ;

Wheeler-Kingshott, CAM ;

Boulby, PA ;

Barker, GJ ;

Sillery, EL ;

Sheehan, K ;

Ciccarelli, O ;

Thompson, AJ ;

Brady, JM ;

Matthews, PM .

NATURE NEUROSCIENCE, 2003, 6 (07) :750-757

[4] The measurement and clinical relevance of brain atrophy in multiple sclerosis [J].

Bermel, RA ;

Bakshi, R .

LANCET NEUROLOGY, 2006, 5 (02) :158-170

[5] 1H-MRS quantification of tNA and tCr in patients with multiple sclerosis:: a meta-analytic review [J].

Caramanos, Z ;

Narayanan, S ;

Arnold, DL .

BRAIN, 2005, 128 :2483-2506

[6] MRI and the diagnosis of multiple sclerosis: expanding the concept of "no better explanation" [J].

Charil, Arnaud ;

Yousry, Tarek A. ;

Rovaris, Marco ;

Barkhof, Frederik ;

De Stefano, Nicola ;

Fazekas, Franz ;

Miller, David H. ;

Montalban, Xavier ;

Simon, Jack H. ;

Polman, Chris ;

Filippi, Massimo .

LANCET NEUROLOGY, 2006, 5 (10) :841-852

[7] Spinal cord spectroscopy and diffusion-based tractography to assess acute disability in multiple sclerosis [J].

Ciccarelli, O. ;

Wheeler-Kingshott, C. A. ;

McLean, M. A. ;

Cercignani, M. ;

Wimpey, K. ;

Miller, D. H. ;

Thompson, A. J. .

BRAIN, 2007, 130 :2220-2231

[8] Guidelines for using proton MR spectroscopy in multicenter clinical MS studies [J].

De Stefano, N. ;

Filippi, M. ;

Miller, D. ;

Pouwels, P. J. ;

Rovira, A. ;

Gass, A. ;

Enzinger, C. ;

Matthews, P. M. ;

Arnold, D. L. .

NEUROLOGY, 2007, 69 (20) :1942-1952

[9] Evidence for widespread axonal damage at the earliest clinical stage of multiple sclerosis [J].

Filippi, M ;

Bozzali, M ;

Rovaris, M ;

Gonen, O ;

Kesavadas, C ;

Ghezzi, A ;

Martinelli, V ;

Grossman, RI ;

Scotti, G ;

Comi, G ;

Falini, A .

BRAIN, 2003, 126 :433-437

[10] Magnetization transfer magnetic resonance imaging of the brain, spinal cord, and optic nerve [J].

Filippi, Massimo ;

Rocca, Maria A. .

NEUROTHERAPEUTICS, 2007, 4 (03) :401-413

← 1 2 3 →