Immune responses to adenoviruses: viral evasion mechanisms and their implications for the clinic

被引：159

作者：

Wold, WSM ^{[1
]}

Doronin, K ^{[1
]}

Toth, K ^{[1
]}

Kuppuswamy, M ^{[1
]}

Lichtenstein, DL ^{[1
]}

Tollefson, AE ^{[1
]}

机构：

[1] St Louis Univ, Sch Med, Dept Mol Biol & Immunol, St Louis, MO 63104 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 1999年 / 11卷 / 04期

关键词：

D O I：

10.1016/S0952-7915(99)80064-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Adenoviruses encode proteins that block responses to interferons, intrinsic cellular apoptosis, killing by CD8(+) cytotoxic T lymphocytes and killing by the death ligands TNF, Fas ligand and TRAIL. The viral proteins are believed to prolong acute and persistent adenovirus infections. The proteins may prove useful in protecting adenovirus gene therapy vectors and transplanted cells from the immune system.

引用

页码：380 / 386

页数：7

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