Could Metabolic Syndrome, Lipodystrophy, and Aging Be Mesenchymal Stem Cell Exhaustion Syndromes?

被引：35

作者：

Mansilla, Eduardo ^{[1
]}

Diaz Aquino, Vanina ^{[1
]}

Zambon, Daniel ^{[2
]}

Horacio Marin, Gustavo ^{[1
]}

Martire, Karina ^{[1
]}

Roque, Gustavo ^{[1
]}

Ichim, Thomas ^{[3
]}

Riordan, Neil H. ^{[3
]}

Patel, Amit ^{[4
]}

Sturla, Flavio ^{[5
]}

Larsen, Gustavo ^{[6
,7
]}

Spretz, Ruben ^{[6
,7
]}

Nunez, Luis ^{[8
,9
]}

Soratti, Carlos ^{[10
]}

Ibar, Ricardo ^{[10
]}

van Leeuwen, Michiel ^{[11
]}

Maria Tau, Jose ^{[1
]}

Drago, Hugo ^{[5
]}

Maceira, Alberto ^{[1
]}

机构：

[1] Minist Hlth, Tissue Engn Regenerat Med & Cell Therapies Lab, CUCAIBA, RA-1900 La Plata, Buenos Aires, Argentina

[2] Hosp Clin Barcelona, Div Endocrinol, Lipid Clin, E-08036 Barcelona, Spain

[3] Medistem Inc, Div Endometrial Regenerat Stem Cells, San Diego, CA 92122 USA

[4] Univ Utah, Div Cardiothorac Surg, Salt Lake City, UT 84132 USA

[5] Burns Hosp, Div Skin Bank, Buenos Aires, DF, Argentina

[6] LNK Chemsolut, Div Nanotechnol, Lincoln, NE 68521 USA

[7] Biotarget, Div Nanotechnol, Denton, NE 68339 USA

[8] Univ Chicago, Div Nanotechnol, Chicago, IL 60637 USA

[9] Nanovogue Inc, Div Intelligent Matrices, Chicago, IL 60126 USA

[10] Minist Hlth, INCUCAI, Buenos Aires, DF, Argentina

[11] Vrije Univ Amsterdam, Burns Div, NL-1081 HV Amsterdam, Netherlands

来源：

STEM CELLS INTERNATIONAL | 2011年 / 2011卷

关键词：

GILFORD-PROGERIA-SYNDROME; HUMAN ADIPOSE-TISSUE; PROGENITOR CELLS; IN-VIVO; ADIPOCYTE PROGENITORS; PERIPHERAL-BLOOD; WHITE ADIPOCYTES; STROMAL CELLS; FAT; TRANSPLANTATION;

D O I：

10.4061/2011/943216

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

One of the most important and complex diseases of modern society is metabolic syndrome. This syndrome has not been completely understood, and therefore an effective treatment is not available yet. We propose a possible stem cell mechanism involved in the development of metabolic syndrome. This way of thinking lets us consider also other significant pathologies that could have similar etiopathogenic pathways, like lipodystrophic syndromes, progeria, and aging. All these clinical situations could be the consequence of a progressive and persistent stem cell exhaustion syndrome (SCES). The main outcome of this SCES would be an irreversible loss of the effective regenerative mesenchymal stem cells (MSCs) pools. In this way, the normal repairing capacities of the organism could become inefficient. Our point of view could open the possibility for a new strategy of treatment in metabolic syndrome, lipodystrophic syndromes, progeria, and even aging: stem cell therapies.

引用

页数：10

共 110 条

[1] Adipocyte Turnover: Relevance to Human Adipose Tissue Morphology [J].

Arner, Erik ;

Westermark, Pal O. ;

Spalding, Kirsty L. ;

Britton, Tom ;

Ryden, Mikael ;

Frisen, Jonas ;

Bernard, Samuel ;

Arner, Peter .

DIABETES, 2010, 59 (01) :105-109

[2] Stem cells and the regeneration of the aging cardiovascular system [J].

Ballard, Victoria L. T. ;

Edelberg, Jay M. .

CIRCULATION RESEARCH, 2007, 100 (08) :1116-1127

[3] The obese healthy paradox: is inflammation the answer? [J].

Barbarroja, Nuria ;

Lopez-Pedrera, Rosario ;

Dolores Mayas, Maria ;

Garcia-Fuentes, Eduardo ;

Garrido-Sánchez, Lourdes ;

Macias-Gonzalez, M. ;

El Bekay, Rajaa ;

Vidal-Puig, Antonio ;

Tinahones, Francisco J. .

BIOCHEMICAL JOURNAL, 2010, 430 :141-149

[4] Cell-delivery therapeutics for adipose tissue regeneration [J].

Bauer-Kreisel, Petra ;

Goepferich, Achim ;

Blunk, Torsten .

ADVANCED DRUG DELIVERY REVIEWS, 2010, 62 (7-8) :798-813

[5] Long-term results after intracoronary injection of autologous mononuclear bone marrow cells in acute myocardial infarction: the ASTAMI randomised, controlled study [J].

Beitnes, J. O. ;

Hopp, E. ;

Lunde, K. ;

Solheim, S. ;

Arnesen, H. ;

Brinchmann, J. E. ;

Forfang, K. ;

Aakhus, S. .

HEART, 2009, 95 (24) :1983-1989

[6] Aging of marrow stromal (skeletal) stem cells and their contribution to age-related bone loss [J].

Bellantuono, Ilaria ;

Aldahmash, Abdullah ;

Kassem, Moustapha .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2009, 1792 (04) :364-370

[7] Aging of Hutchinson-Gilford progeria syndrome fibroblasts is characterised by hyperproliferation and increased apoptosis [J].

Bridger, JM ;

Kill, IR .

EXPERIMENTAL GERONTOLOGY, 2004, 39 (05) :717-724

[8] Nuclear lamins: Laminopathies and their role in premature ageing [J].

Broers, J. L. V. ;

Ramaekers, F. C. S. ;

Bonne, G. ;

Ben Yaou, R. ;

Hutchison, C. J. .

PHYSIOLOGICAL REVIEWS, 2006, 86 (03) :967-1008

[9] Perturbation of wild-type lamin A metabolism results in a progeroid phenotype [J].

Candelario, Jose ;

Sudhakar, Sivasubramaniam ;

Navarro, Sonia ;

Reddy, Sita ;

Comai, Lucio .

AGING CELL, 2008, 7 (03) :355-367

[10] Diseases of adipose tissue:: genetic and acquired lipodystrophies [J].

Capeau, J ;

Magré, J ;

Lascols, O ;

Caron, M ;

Béréziat, V ;

Vigouroux, C ;

Bastard, JP .

BIOCHEMICAL SOCIETY TRANSACTIONS, 2005, 33 :1073-1077

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