Psoriasis Pathogenesis and Treatment

被引：1439

作者：

Rendon, Adriana ^{[1
]}

Schaekel, Knut ^{[1
]}

机构：

[1] Heidelberg Univ, Dept Dermatol, D-69120 Heidelberg, Germany

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2019年 / 20卷 / 06期

关键词：

psoriasis; inflammation; chronic skin disease; GENOME-WIDE ASSOCIATION; NF-KAPPA-B; CHRONIC PLAQUE PSORIASIS; FUMARIC-ACID ESTERS; TO-SEVERE PSORIASIS; GENERALIZED PUSTULAR PSORIASIS; PATIENT-REPORTED OUTCOMES; DERMAL DENDRITIC CELLS; LONG NONCODING RNAS; ACTIVITY IN-VITRO;

D O I：

10.3390/ijms20061475

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Research on psoriasis pathogenesis has largely increased knowledge on skin biology in general. In the past 15 years, breakthroughs in the understanding of the pathogenesis of psoriasis have been translated into targeted and highly effective therapies providing fundamental insights into the pathogenesis of chronic inflammatory diseases with a dominant IL-23/Th17 axis. This review discusses the mechanisms involved in the initiation and development of the disease, as well as the therapeutic options that have arisen from the dissection of the inflammatory psoriatic pathways. Our discussion begins by addressing the inflammatory pathways and key cell types initiating and perpetuating psoriatic inflammation. Next, we describe the role of genetics, associated epigenetic mechanisms, and the interaction of the skin flora in the pathophysiology of psoriasis. Finally, we include a comprehensive review of well-established widely available therapies and novel targeted drugs.

引用

页数：28

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