Palladium-Catalyzed Heck Cross-Coupling Reactions in Water: A Comprehensive Review

被引：129

作者：

Christoffel, Fadri ^{[1
]}

Ward, Thomas R. ^{[1
]}

机构：

[1] Univ Basel, Dept Chem, BRP Rosental 1096,Mattenstr 24a, CH-4058 Basel, Switzerland

来源：

CATALYSIS LETTERS | 2018年 / 148卷 / 02期

基金：

瑞士国家科学基金会;

关键词：

Cross-coupling; Palladium; Aqueous catalysis; Green chemistry; Heck-Mizoroki reaction; N-HETEROCYCLIC CARBENES; METATHESIS POLYMERIZATION ROMP; AQUEOUS-PHASE HECK; MIZOROKI-HECK; SUZUKI-MIYAURA; ROOM-TEMPERATURE; ARYL HALIDES; LIGAND-FREE; ARTIFICIAL METALLOENZYMES; HETEROGENEOUS CATALYSTS;

D O I：

10.1007/s10562-017-2285-0

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Palladium-catalyzed cross-coupling reactions have emerged as one of the most versatile tools in organic chemistry. Extensive efforts were made to adapt these reactions to aqueous media, not only for the purpose of environmental conservation but also to expand the scope, increase the efficiency and implement bio-compatible protocols. Among different palladium cross-coupling reactions, the Heck reaction turned out to be the most challenging in an aqueous environment. This led to various original developments in catalyst design. This review summarizes the different approaches pursued to perform Heck reactions in neat water as well as aqueous mixtures. Both, homogeneous and immobilized catalysts, including nanoparticles are presented herein. Graphical Abstract [GRAPHICS] .

引用

页码：489 / 511

页数：23

共 135 条

[91] Metabolic alkene labeling and in vitro detection of histone acylation via the aqueous oxidative Heck reaction [J].