Phthalate metabolites and biomarkers of oxidative stress in the follicular fluid of women undergoing in vitro fertilization

被引:36
作者
Yuan, Xiao-Qiong [1 ]
Du, Yao-Yao [1 ]
Liu, Chong [2 ,3 ,4 ]
Guo, Na [1 ]
Teng, Xue-Mei [1 ]
Hua, Xiang [1 ]
Yao, Yang-Cheng [1 ]
Deng, Yan-Ling [2 ,3 ,4 ]
Zeng, Qiang [2 ,3 ,4 ]
Deng, Tao-Ran [1 ]
Li, Yu-Feng [1 ]
机构
[1] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Reprod Med Ctr, 1095 Jiefang Ave, Wuhan, Hubei, Peoples R China
[2] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Dept Occupat & Environm Hlth, Wuhan, Hubei, Peoples R China
[3] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Key Lab Environm & Hlth,Minist Educ, Wuhan, Hubei, Peoples R China
[4] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Minist Environm Protect,State Key Lab Environm Hl, Wuhan, Hubei, Peoples R China
关键词
IVF women; Phthalates; Oxidative stress; Follicular fluid; URINARY CONCENTRATIONS; INFERTILE WOMEN; HUMAN EXPOSURE; PREGNANCY LOSS; BISPHENOL-A; ASSOCIATION; HEALTH; DAMAGE; CELLS; DNA;
D O I
10.1016/j.scitotenv.2020.139834
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Epidemiological studies have suggested that phthalate exposures were associated with adverse reproductive outcomes, such as low oocyte yield and reduced embryo quality, but the underlying mechanisms remained largely unknown. Oxidative stress may be a potential contributor to phthalate-induced adverse reproductive outcomes. To explore the associations between phthalate exposure and levels of oxidative stress among women seeking in vitro fertilization (IVF), we measured the concentrations of eight phthalate metabolites and bio-markers of oxidative stress, including 8-hydroxy-2'-deoxyguanosine (8-OHdG), malondialdehyde (MDA), and total antioxidant capacity (TAC), in follicular fluid (IT) samples collected from 332 women. Multivariable linear regression models were used to assess the associations between phthalate metabolites and biomarkers of oxida-tive stress in FF samples. The concentrations of most tested phthalate metabolites were positively associated with the 8-OHdG levels. The metabolites of di-(2-ethylhexyl) phthalate (DEHP) were inversely associated with the TAC levels. The concentrations of mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP) and mono(2-ethyl-5-oxohexyl) phthalate (MEOHP) were positively associated with the MDA levels. Our results revealed a positive as-sociation between phthalate metabolites and oxidative stress levels in IT, while more toxicological and epidemiological studies are required to confirm our findings. (C) 2020 Elsevier B.V. All rights reserved.
引用
收藏
页数:8
相关论文
共 67 条
  • [1] Oxidative stress and its implications in female infertility - a clinician's perspective
    Agarwal, A
    Gupta, S
    Sharma, R
    [J]. REPRODUCTIVE BIOMEDICINE ONLINE, 2005, 11 (05) : 641 - 650
  • [2] The effects of oxidative stress on female reproduction: a review
    Agarwal, Ashok
    Aponte-Mellado, Anamar
    Premkumar, Beena J.
    Shaman, Amani
    Gupta, Sajal
    [J]. REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY, 2012, 10
  • [3] Exposure to phthalates in couples undergoing in vitro fertilization treatment and its association with oxidative stress and DNA damage
    Al-Saleh, Iman
    Coskun, Serdar
    Al-Doush, Inaam
    Al-Rajudi, Tahreer
    Al Rouqi, Reem
    Abduljabbar, Mai
    Al-Hassan, Saad
    [J]. ENVIRONMENTAL RESEARCH, 2019, 169 : 396 - 408
  • [4] Urinary biomarkers of exposure to 57 xenobiotics and its association with oxidative stress in a population in Jeddah, Saudi Arabia
    Asimakopoulos, Alexandros G.
    Xue, Jingchuan
    De Carvalho, Bruno Pereira
    Iyer, Archana
    Abualnaja, Khalid Omer
    Yaghmoor, Soonham Sami
    Kumosani, Taha Abdullah
    Kannan, Kurunthachalam
    [J]. ENVIRONMENTAL RESEARCH, 2016, 150 : 573 - 581
  • [5] Barbara Ambruosi M.F.U.A, 2011, LARGE ANIMAL MODEL
  • [6] The effects of work-related maternal risk factors on time to pregnancy, preterm birth and birth weight: the Generation R Study
    Burdorf, A.
    Brand, T.
    Jaddoe, V. W.
    Hofman, A.
    Mackenbach, J. P.
    Steegers, E. A. P.
    [J]. OCCUPATIONAL AND ENVIRONMENTAL MEDICINE, 2011, 68 (03) : 197 - 204
  • [7] Di-(2-ethylhexyl)-phthalate induces oxidative stress in human endometrial stromal cells in vitro
    Cho, Yeon Jean
    Park, Seung Bin
    Han, Myoungseok
    [J]. MOLECULAR AND CELLULAR ENDOCRINOLOGY, 2015, 407 (0C) : 9 - 17
  • [8] Oocyte oxidative DNA damage may be involved in minimal/mild endometriosis-related infertility
    Da Broi, Michele G.
    Jordao-, Alceu A., Jr.
    Ferriani, Rui A.
    Navarro, Paula A.
    [J]. MOLECULAR REPRODUCTION AND DEVELOPMENT, 2018, 85 (02) : 128 - 136
  • [9] Increased concentration of 8-hydroxy-2′-deoxyguanosine in follicular fluid of infertile women with endometriosis
    Da Broi, Michele G.
    de Albuquerque, Felipe O.
    de Andrade, Aline Z.
    Cardoso, Rafaela L.
    Jordao Junior, Alceu A.
    Navarro, Paula A.
    [J]. CELL AND TISSUE RESEARCH, 2016, 366 (01) : 231 - 242
  • [10] Follicular fluid and urinary concentrations of phthalate metabolites among infertile women and associations with in vitro fertilization parameters
    Du, Yao-Yao
    Fang, Yue-Li
    Wang, Yi-Xin
    Zeng, Qiang
    Guo, Na
    Zhao, Hua
    Li, Yu-Feng
    [J]. REPRODUCTIVE TOXICOLOGY, 2016, 61 : 142 - 150