Magnetic lipid nanocapsules (MLNCs): self-assembled lipid-based nanoconstruct for non-invasive theranostic applications

被引：16

作者：

Nandwana, Vikas ^{[1
,2
]}

Singh, Abhalaxmi ^{[1
,2
]}

You, Marisa M. ^{[1
]}

Zhang, Gefei ^{[1
]}

Higham, John ^{[1
,3
]}

Zheng, Tiffany S. ^{[1
]}

Li, Yue ^{[1
]}

Prasad, Pottumarthi V. ^{[4
]}

Dravid, Vinayak P. ^{[1
,2
]}

机构：

[1] Northwestern Univ, Dept Mat Sci & Engn, Evanston, IL 60208 USA

[2] Int Inst Nanotechnol, Evanston, IL 60208 USA

[3] Univ Notre Dame, Dept Biomed Engn, Notre Dame, IN 46556 USA

[4] Northshore Univ Healthcare, Dept Radiol, Evanston, IL 60201 USA

来源：

JOURNAL OF MATERIALS CHEMISTRY B | 2018年 / 6卷 / 07期

关键词：

IRON-OXIDE NANOPARTICLES; RESONANCE-IMAGING CONTRAST; DRUG-DELIVERY SYSTEMS; FUNCTIONAL MATERIALS; CONTROLLED-RELEASE; LIPOSOMES; AGENTS; MAGNETOLIPOSOMES; CLUSTERS; THERAPY;

D O I：

10.1039/c7tb03160b

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

We report magnetic nanostructure-stabilized lipid nanocapsules (MLNCs) that show superior structural stability and theranostic properties compared to conventional lipid-based nanocarriers. As therapeutic nanocarriers, the MLNCs exhibit a therapeutic efficacy that is 16 times greater than that of free drugs due to their high payload capacity and actuated drug release ability. In addition, the magnetic resonance contrast enhancement of the MLNCs is nine times higher than that of a clinically approved T-2 MRI contrast agent (ferumoxytol), demonstrating the diagnostic imaging capability of the MLNCs in MRI. The self-assembly method to synthesize the lipid nanocapsules is extended to other types of nanoparticles (gold nanoparticles and quantum dots) to produce lipid nanohybrids with distinct physical properties.

引用

页码：1026 / 1034

页数：9

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