KCa(H2O)2[FeIII(CN)6]•H2O Nanoparticles as an Antimicrobial Agent against Staphylococcus aureus

被引：18

作者：

Wang, Zhongxia ^{[1
]}

Yu, Bing ^{[2
]}

Alamri, Huda ^{[1
]}

Yarabarla, Sriramakrishna ^{[1
]}

Kim, Min-Ho ^{[2
]}

Huang, Songping D. ^{[1
]}

机构：

[1] Kent State Univ, Dept Chem & Biochem, Kent, OH 44240 USA

[2] Kent State Univ, Dept Biol Sci, Kent, OH 44240 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2018年 / 57卷 / 08期

关键词：

antimicrobial activity; biocompatible nanoparticles; iron depletion; iron metabolism; Prussian blue analogue; MICROBIAL IRON TRANSPORT; ESCHERICHIA-COLI; METABOLISM; SIDEROPHORES; ENTEROBACTIN; INFECTIONS; BACTERIA;

D O I：

10.1002/anie.201713177

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Biocompatible nanoparticles based on a calcium analogue of Prussian blue were designed and synthesized to take advantage of their ability to penetrate the cell membrane in Staphylococcus aureus and to undergo selective ion exchange with intracellular iron to disrupt iron metabolism in such pathogenic bacteria for antibacterial applications. KCa(H2O)(2)[Fe-III(CN)(6)]center dot H2O nanoparticles penetrate the bacterial cell membrane and sequester intracellular iron by ion exchange to form insoluble Prussian blue, thus inhibiting bacterial growth.

引用

页码：2214 / 2218

页数：5

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