Transfusions of CPDA-1 red blood cells stored for up to 28 days decrease donor exposures in very low-birth-weight premature infants

被引：39

作者：

da Cunha, DHF ^{[1
]}

dos Santos, AMN ^{[1
]}

Kopelman, BI ^{[1
]}

Areco, KN ^{[1
]}

Guinsburg, R ^{[1
]}

Peres, CD ^{[1
]}

Chiba, AK ^{[1
]}

Kuwano, ST ^{[1
]}

Terzian, CCN ^{[1
]}

Bordin, JO ^{[1
]}

机构：

[1] Univ Fed Sao Paulo, Dept Pediat, Div Neonatol Med, Hematol & Transfus Med Serv,Dept Biostat, Sao Paulo, Brazil

来源：

TRANSFUSION MEDICINE | 2005年 / 15卷 / 06期

关键词：

blood donors; erythrocyte transfusion; hyperkalaemia; infant newborn; neonatal anaemia; premature infants;

D O I：

10.1111/j.1365-3148.2005.00624.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The goal of this research was to study the safety and the efficacy of transfusing citrate-phosphate-adenine anticoagulant-preservative (CPDA-1) RBC stored for up to 28 days to reduce donor exposures in premature infants. A prospective randomized two-group study was conducted with very low-birth-weight premature infants that received at least one RBC transfusion during hospital stay. Neonates randomly assigned to Group 1 (26 infants) were transfused with CPDA-1 RBC stored for up to 28 days; those assigned to Group 2 (26 infants) received CPDA-1 RBC stored for up to 3 days. Demographic and transfusion-related data were collected. Neonates from both groups showed similar demographics and clinical characteristics. The number of transfusions per infant transfused was 4.4 +/- 4.0 in Group 1 and 4.2 +/- 3.1 in Group 2, and the number of donors per infant transfused was 1.5 +/- 0.8 (Group 1) and 4.3 +/- 3.4 (Group 2), P < 0.001. RBC transfusions containing 29.7 +/- 18.3 mmol L-1 of potassium (RBC stored for up to 28 days) did not cause clinical or biochemical changes and reduced donor exposures by 70.2%, compared to transfusions containing 19.8 +/- 12.3 mmol L-1 of potassium (RBC stored for up to 3 days), P < 0.001. In conclusion, RBC stored for up to 28 days safely reduced donor exposures in premature infants.

引用

页码：467 / 473

页数：7

共 19 条

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