Clinical effectiveness of unilateral deep brain stimulation in Tourette syndrome

被引：19

作者：

Kuhn, J. ^{[1
]}

Bartsch, C. ^{[1
]}

Lenartz, D. ^{[2
]}

Huys, D. ^{[1
]}

Daumann, J. ^{[1
]}

Woopen, C. ^{[3
,4
]}

Hunsche, S. ^{[2
]}

Maarouf, M. ^{[2
]}

Klosterkoetter, J. ^{[1
]}

Sturm, V. ^{[2
]}

机构：

[1] Univ Cologne, Dept Psychiat & Psychotherapy, D-50937 Cologne, Germany

[2] Univ Cologne, Dept Stereotaxy & Funct Neurosurg, D-50937 Cologne, Germany

[3] Univ Cologne, Inst Hist Med & Med Eth, D-50937 Cologne, Germany

[4] Univ Hosp, Cologne, Germany

来源：

TRANSLATIONAL PSYCHIATRY | 2011年 / 1卷

关键词：

deep brain stimulation; motor-loop activity; thalamus; Tourette syndrome; unilateral stimulation; NUCLEUS-ACCUMBENS;

D O I：

10.1038/tp.2011.51

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Dysfunctional basal ganglia loops are thought to underlie the clinical picture of Tourette syndrome (TS). By altering dopaminergic activity in the affected neural structures, bilateral deep brain stimulation is assumed to have a modulatory effect on dopamine transmission resulting in an amelioration of tics. While the majority of published case reports deals with the application of bilateral stimulation, the present study aims at informing about the high effectiveness of unilateral stimulation of pallidal and nigral thalamic territories in TS. Potential implications and gains of the unilateral approach are discussed. Translational Psychiatry (2011) 1, e52; doi: 10.1038/tp.2011.51; published online 15 November 2011

引用

页码：e52 / e52

页数：4

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