The role of tonic and phasic dopamine for long-term synaptic plasticity in the prefrontal cortex: A computational model

被引：15

作者：

Sheynikhovich, Denis ^{[1
]}

Otani, Satoru ^{[2
]}

Arleo, Angelo ^{[1
]}

机构：

[1] Univ Paris 06, Lab Neurobiol Adapt Proc, CNRS, UMR7102, F-75005 Paris, France

[2] Univ Paris 06, Lab Psychopathol Cent Nervous Syst Dis, INSERM, U952,CNRS,UMR7224, F-75005 Paris, France

来源：

JOURNAL OF PHYSIOLOGY-PARIS | 2011年 / 105卷 / 1-3期

关键词：

Prefrontal cortex; Long-term potentiation; Long-term depression; Dopamine; Computational model; TIMING-DEPENDENT PLASTICITY; WORKING-MEMORY; CORTICAL-NEURONS; POSTSYNAPTIC ACTIVATION; INTEGRATIVE THEORY; LATE MAINTENANCE; D1; RECEPTORS; IN-VITRO; POTENTIATION; MODULATION;

D O I：

10.1016/j.jphysparis.2011.08.001

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

This work presents a computational model of dopamine (DA) influence on long-term potentiation (LIP) and long-term depression (LTD) in the prefrontal cortex. Distinct properties of the model are a DA-concentration-dependent switch from depression to potentiation during induction of plasticity, and an inverted-U-shaped dependence of protein synthesis on the level of background DA. Protein synthesis is responsible for the maintenance of LIP/LTD in the model. Our simulations suggest that in vitro experimental data on prefrontal plasticity, induced by high-frequency stimulation, may be accounted for by a single synaptic mechanism that is slowly (on the timescale of minutes) activated in the presence of DA in a concentration-dependent manner. The activation value determines the direction of plasticity during induction, while it also modulates the magnitude of plasticity during maintenance. More generally, our results support the hypothesis that phasic release of endogenous DA is necessary for the maintenance of long-term changes in synaptic efficacy, while the concentration of tonic DA determines the direction and magnitude of these changes in the PFC. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：45 / 52

页数：8

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