Aberrant Expression Levels of MTA1 and RECK in Nasopharyngeal Carcinoma: Association With Metastasis, Recurrence, and Prognosis

被引:15
作者
Deng, Yan Fei [1 ,3 ]
Zhou, Dong Ni [2 ]
Ye, Chun Sheng [3 ]
Zeng, Liang [4 ]
Yin, Ping [2 ]
机构
[1] Xiamen Univ, Zhongshan Hosp, Dept Otolaryngol Head & Neck Surg, Xiamen, Peoples R China
[2] Xiamen Univ, Zhongshan Hosp, Dept Pathol, Xiamen, Peoples R China
[3] Fujian Med Univ, Zhongshan Hosp, Dept Otolaryngol Head & Neck Surg, Xiamen, Peoples R China
[4] Tumor Hosp Hunan Prov, Dept Pathol, Changsha, Peoples R China
关键词
in situ hybridization; MTA1; nasopharyngeal carcinoma; RECK; SQUAMOUS-CELL CARCINOMAS; SUPPRESSOR RECK; DOWN-REGULATION; LUNG-CANCER; INVASION; PROTEIN; GENE; ADENOCARCINOMA; DEACETYLATION; INVOLVEMENT;
D O I
10.1177/000348941212100706
中图分类号
R76 [耳鼻咽喉科学];
学科分类号
100213 ;
摘要
Objectives: We investigated the expression and clinical value of MTA1 and RECK genes in patients with nasopharyngeal carcinoma (NPC). Methods: We examined MTA1 and RECK expression in nasopharyngeal tissue from patients with chronic nasopharyngitis, lymph nodes with metastasis of NPC, and primary NPC tumor tissue by means of in situ hybridization and analyzed their correlation with the clinicopathologic features of NPC. Results: The positive expression of MTA1 in the NPC tissues and metastatic lymph nodes was significantly higher than that in the chronic nasopharyngitis tissues (p < 0.05). The positive expression of RECK in the NPC tissues and metastatic lymph nodes was significantly lower than that in the chronic nasopharyngitis tissues (p < 0.05). The RECK expression level was inversely correlated with the MTA1 expression level in the NPC tissues (p < 0.05). The increased MTA1 and decreased RECK expressions in the NPC tissues had no association with gender, age, T-stage, or clinical stage (p > 0.05). However, they had a positive correlation with cervical lymph node metastasis, tumor recurrence, and 5-year overall survival rate of the patients with NPC (p < 0.05). Moreover, multivariate analysis showed that MTA1 and RECK expressions were independent prognostic factors for survival (p < 0.05). Conclusions: The conversely abnormal expression levels of MTA1 and RECK may be collectively involved in progression of malignancies and may serve as molecular predictors for metastasis, recurrence, and prognosis of NPC.
引用
收藏
页码:457 / 465
页数:9
相关论文
共 24 条
[1]   Involvement of HER-2/neu and metastasis-related proteins in the development of ileal neuroendocrine tumors [J].
Azzoni, Cinzia ;
Bottarelli, Lorena ;
Cecchini, Stefano ;
Lagrasta, Costanza ;
Pizzi, Silvia ;
D'Adda, Tiziana ;
Tamburini, Elisa ;
Rindi, Guido ;
Bordi, Cesare .
VIRCHOWS ARCHIV, 2011, 458 (05) :525-536
[2]  
Barnes L., 2005, WHO CLASSIFICATION T, P81
[3]   Involvement of histone deacetylation in ras-induced down-regulation of the metastasis suppressor RECK [J].
Chang, HC ;
Liu, LT ;
Hung, WC .
CELLULAR SIGNALLING, 2004, 16 (06) :675-679
[4]   Downregulation of RECK by promoter methylation correlates with lymph node metastasis in non-small cell lung cancer [J].
Chang, Huang-Chou ;
Cho, Chun-Yu ;
Hung, Wen-Chun .
CANCER SCIENCE, 2007, 98 (02) :169-173
[5]   RECK - a newly discovered inhibitor of metastasis with prognostic significance in multiple forms of cancer [J].
Clark, Jonathan C. M. ;
Thomas, David M. ;
Choong, Peter F. M. ;
Dass, Crispin R. .
CANCER AND METASTASIS REVIEWS, 2007, 26 (3-4) :675-683
[6]   HER-2/neu represses the metastasis suppressor RECK via ERK and Sp transcription factors to promote cell invasion [J].
Hsu, MC ;
Chang, HC ;
Hung, WC .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (08) :4718-4725
[7]   Inhibition of Histone Deacetylase Attenuates Hypoxia-Induced Migration and Invasion of Cancer Cells via the Restoration of RECK Expression [J].
Jeon, Hye Won ;
Lee, You Mie .
MOLECULAR CANCER THERAPEUTICS, 2010, 9 (05) :1361-1370
[8]   Overexpression of metastasis-associated MTA1 in oral squamous cell carcinomas: correlation with metastasis and invasion [J].
Kawasaki, G. ;
Yanamoto, S. ;
Yoshitomi, I. ;
Yamada, S. ;
Mizuno, A. .
INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 2008, 37 (11) :1039-1046
[9]   Downregulation of a tumor suppressor RECK by hypoxia through recruitment of HDAC1 and HIF-1α to reverse HRE site in the promoter [J].
Lee, Kyung Ju ;
Lee, Kwang Youl ;
Lee, You Mie .
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2010, 1803 (05) :608-616
[10]   MTA1 Coregulator Regulates p53 Stability and Function [J].
Li, Da-Qiang ;
Reddy, Sirigiri Divijendra Natha ;
Pakala, Suresh B. ;
Wu, Xifeng ;
Zhang, Yanping ;
Rayala, Suresh K. ;
Kumar, Rakesh .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2009, 284 (50) :34545-34552