Apolipoprotein E, an important player in longevity and age-related diseases

被引：58
作者：
Ang, Lisa S. [1 ]
Cruz, Rani P. [1 ]
Hendel, Alon [1 ]
Granville, David J. [1 ]
机构：
[1] Univ British Columbia, Dept Pathol & Lab Med, St Pauls Hosp, Providence Heart Lung Inst, Vancouver, BC V6Z 1Y6, Canada
来源：
EXPERIMENTAL GERONTOLOGY | 2008年 / 43卷 / 07期
关键词：
apolipoprotein E; aging; atherosclerosis; Alzheimer's; allele; mouse model;
D O I：
10.1016/j.exger.2008.03.010
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Numerous murine models are available for the study of the human aging process. Most of these models are based on known mutations that cause progeroid disease in humans or are involved in DNA repair and cell senescence. While these models certainly have contributed to our knowledge of age-related diseases, none adequately represent the range of human ailments involving cardiovascular and neurocognitive deterioration. In the current review, we summarize the available murine models of aging to date. We then discuss the known involvement of apolipoprotein E (ApoE) in various symptoms of the human aging process and describe the corresponding age-related phenotypes presented by the ApoE knockout mouse. (C) 2008 Elsevier Inc. All rights reserved.
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收藏
页码：615 / 622
页数：8
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