Enabling Prussian Blue with Tunable Localized Surface Plasmon Resonances: Simultaneously Enhanced Dual-Mode Imaging and Tumor Photothermal Therapy

被引：146

作者：

Cai, Xiaojun ^{[1
,2
]}

Gao, Wei ^{[3
]}

Zhang, Linlin ^{[1
,2
]}

Ma, Ming ^{[1
]}

Liu, Tianzhi ^{[1
,2
]}

Du, Wenxian ^{[1
,2
]}

Zheng, Yuanyi ^{[3
]}

Chen, Hangrong ^{[1
]}

Shi, Jianlin ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China

[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

[3] Shanghai Jiao Tong Univ, Sch Med, Shanghai Peoples Hosp 6, Shanghai 200233, Peoples R China

来源：

ACS NANO | 2016年 / 10卷 / 12期

基金：

中国国家自然科学基金;

关键词：

Prussian blue; tunable localized surface plasmon resonances; magnetic resonance imaging; photoacoustic imaging; photothermal therapy; reactive oxygen species scavenger; COATED GOLD NANOPARTICLES; LONG-TERM STABILITY; SENSING APPLICATIONS; OXIDE NANOCRYSTALS; QUALITY ASSESSMENT; THERANOSTIC AGENT; THALLIUM BINDING; WATER-CONTENT; CANCER; METAL;

D O I：

10.1021/acsnano.6b05990

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Prussian blue (PB) has been used as a photothermal conversion agent to generate heat to induce localized damage "to tumor. However, its therapeutic efficiency is far from satisfactory. One of the major obstacles is that the maximum NIR absorption peak of PB within 690-720 nm cannot be optimized near the wavelength of the laser to enhance its therapeutic efficiency. Herein, we report that the integration of Gd3+ into PB nanocrystals (GPB NCs) enables PB with tunable localized surface plasmon resonances (LSPRs) from 710 to 910 nm, achieving the maximum NIR peak near the wavelength of the laser. Concurrently, the efficiency of dual-mode imaging including photo acoustic imaging and magnetic resonance imaging has been greatly improved. These enhancements in dual-mode imaging and photo thermal therapy enable PB with low nanomaterial dose and laser flux. Additionally, it is found that GPB NCs show the capability of not only acting as a chemical probe with tunable sensitivity but also scavenging reactive functional ions into a photothermal conversion agent is an efficient strategy to enchanting tumor theranostic efficiency. oxygen species. The integration of improve the synergy of nanoagent,

引用

页码：11115 / 11126

页数：12

共 47 条

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