Direct Amination of Azoles via Catalytic C-H, N-H Coupling

被引：347

作者：

Monguchi, Daiki ^{[1
]}

Fujiwara, Taiki ^{[1
]}

Furukawa, Hirotoshi ^{[1
]}

Mori, Atsunori ^{[1
]}

机构：

[1] Kobe Univ, Dept Sci & Chem Engn, Kobe, Hyogo 6578501, Japan

来源：

ORGANIC LETTERS | 2009年 / 11卷 / 07期

关键词：

BOND FORMATION; DIRECT ARYLATION; ARYL HALIDES; EFFICIENT; FUNCTIONALIZATION; 2,5-DIARYLTHIAZOLE; BROMOTHIOPHENE; DERIVATIVES; AMIDATION; ACTIVATOR;

D O I：

10.1021/ol900298e

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

C-H, N-H Coupling of azoles takes place with several amines in the presence of a copper catalyst to undergo amination at the 2-position. The reaction of benzothiazole with N-methylaniline in the presence of sodium acetate and 20 mol % Cu(OAc)(2) in xylene under an oxygen atmosphere afforded the aminated product in 81% yield.

引用

页码：1607 / 1610

页数：4

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