(β-D-Ribofuranosyl)formamidine in the Design and Synthesis of 2-(β-D-Ribofuranosyl)pyrimidines, Including RF-Containing Derivatives

被引：14

作者：

Iaroshenko, Viktor O. ^{[1
,2
]}

Dudkin, Sergii ^{[1
]}

Sosnovskikh, Vyacheslav Ya. ^{[3
]}

Villinger, Alexander ^{[1
]}

Langer, Peter ^{[1
,4
]}

机构：

[1] Univ Rostock, Inst Chem, D-18059 Rostock, Germany

[2] Natl Taras Shevchenko Univ, UA-01033 Kiev, Ukraine

[3] Ural Fed Univ, Dept Chem, Ekaterinburg 620000, Russia

[4] Univ Rostock eV, Leibniz Inst Katalyse, D-18059 Rostock, Germany

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2013年 / 2013卷 / 15期

关键词：

Nucleosides; Drug design; Drug discovery; Fluorine; Ribonucleosides; Alkynes; REGIOSELECTIVE SYNTHESIS; MEDICINAL CHEMISTRY; HETERO ANALOGS; FLUORINE; NUCLEOSIDES; 3-(POLYHALOACYL)CHROMONES; TRANSFORMATION;

D O I：

10.1002/ejoc.201300107

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A wide range of novel 2-(beta-D-ribofuranosyl)pyrimidines, including R-F-containing derivatives, have been synthesized by the reaction of (beta-D-ribofuranosyl)formamidine with various dielectrophilic substrates such as 3-alkoxy- and 3-chloro-1-(polyfluoroalkyl)propen-1-ones, 3-nitro- and 3-(phenyl-ethynyl) chromones and heteroaryl acetylenic ketones.

引用

页码：3166 / 3173

页数：8

共 47 条

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