(β-D-Ribofuranosyl)formamidine in the Design and Synthesis of 2-(β-D-Ribofuranosyl)pyrimidines, Including RF-Containing Derivatives

被引：14
|
作者：
Iaroshenko, Viktor O. [1 ,2 ]
Dudkin, Sergii [1 ]
Sosnovskikh, Vyacheslav Ya. [3 ]
Villinger, Alexander [1 ]
Langer, Peter [1 ,4 ]
机构：
[1] Univ Rostock, Inst Chem, D-18059 Rostock, Germany
[2] Natl Taras Shevchenko Univ, UA-01033 Kiev, Ukraine
[3] Ural Fed Univ, Dept Chem, Ekaterinburg 620000, Russia
[4] Univ Rostock eV, Leibniz Inst Katalyse, D-18059 Rostock, Germany
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2013年 / 2013卷 / 15期
关键词：
Nucleosides; Drug design; Drug discovery; Fluorine; Ribonucleosides; Alkynes; REGIOSELECTIVE SYNTHESIS; MEDICINAL CHEMISTRY; HETERO ANALOGS; FLUORINE; NUCLEOSIDES; 3-(POLYHALOACYL)CHROMONES; TRANSFORMATION;
D O I：
10.1002/ejoc.201300107
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A wide range of novel 2-(beta-D-ribofuranosyl)pyrimidines, including R-F-containing derivatives, have been synthesized by the reaction of (beta-D-ribofuranosyl)formamidine with various dielectrophilic substrates such as 3-alkoxy- and 3-chloro-1-(polyfluoroalkyl)propen-1-ones, 3-nitro- and 3-(phenyl-ethynyl) chromones and heteroaryl acetylenic ketones.
引用
收藏
页码：3166 / 3173
页数：8
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