Structure-activity relationship of thiopyrimidines as mGluR5 antagonists

被引：12

作者：

Hammerland, LG

Johansson, M

Malmström, J

Mattsson, JP

Minidis, ABE ^{[1
]}

Nilsson, K

Peterson, A

Wensbo, D

Wållberg, A

Österlund, K

机构：

[1] Astra Zeneca R&D Sodertalje, Local Discovery CNS & Pain Control, Med Chem, SE-15185 Sodertalje, Sweden

[2] NPS Pharmaceut, Salt Lake City, UT 84108 USA

[3] Astra Zeneca R&D Molndal, Med Chem, SE-43183 Molndal, Sweden

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2006年 / 16卷 / 09期

关键词：

thiopyrimidine; metabotropic glutamate receptor; mGluR5;

D O I：

10.1016/j.bmcl.2006.01.100

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Structure-activity relationship investigations of the thiopyrimidine (1), an HTS hit with micromolar activity as a metabotropic glutamate receptor 5 (mGluR5) antagonist, led to compounds with sub-micromolar activity. (C) 2006 Elsevier Ltd. All rights reserved.

引用

收藏

页码：2467 / 2469

页数：3

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