One-pot sequential reactions for the synthesis of versatile 11C-labeled olefin frameworks

被引：4

作者：

Takashima, Misato ^{[1
]}

Kato, Koichi ^{[2
]}

Ogawa, Mikako ^{[1
]}

Magata, Yasuhiro ^{[1
]}

机构：

[1] Hamamatsu Univ, Sch Med, Med Photon Res Ctr, Hamamatsu, Shizuoka 4313192, Japan

[2] Natl Ctr Neurol & Psychiat, Dept Integrat Brain Imaging, Kodaira, Tokyo 1878551, Japan

来源：

RSC ADVANCES | 2013年 / 3卷 / 44期

基金：

日本学术振兴会;

关键词：

BORONIC ACID-ESTERS; RAPID METHYLATION; CARBON FRAMEWORKS; PET TRACERS; EMISSION; IODIDE;

D O I：

10.1039/c3ra43636e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A simple and efficient methodology to construct C-11-labeled olefins (5) was developed. The method involves two different C-C bond-forming reactions: C-11-methylation of a phosphonate (2) using [C-11] methyl iodide (1) and subsequent HWE reaction of C-11-methylated phosphonate (3) with aldehydes (4). Tetrabutylammonium fluoride promoted both C-C bond-forming reactions efficiently as a base. This sequential reaction was conducted in one pot. A wide variety of alpha-[C-11] methyl-alpha,beta-unsaturated compounds were prepared by changing the substituents on the phosphonate and the aldehyde.

引用

页码：21275 / 21279

页数：5

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