PML nuclear bodies and their spatial relationships in the mammalian cell nucleus

被引:16
作者
Batty, Elizabeth [1 ]
Jensen, Kirsten [1 ]
Freemont, Paul [1 ]
机构
[1] Univ London Imperial Coll Sci Technol & Med, Div Mol Biosci, Macromol Struct & Funct Lab, London SW7 2AZ, England
来源
FRONTIERS IN BIOSCIENCE-LANDMARK | 2009年 / 14卷
基金
英国生物技术与生命科学研究理事会;
关键词
PML; PML Nuclear Bodies; DNA damage; MHC; PML Nuclear Body Function; Nuclear Organization; Nuclear Architecture; Nuclear Compartments; Mammalian Nucleus; Spatial Organization; Spatial Relationships; Spatial Associations; Co-Localization; Immunofluorescence; Transcription; DNA Replication; Centromeres; Telomeres; Nucleoli; Chromatin; Proteolysis; Viral Response; Interferon; Stress; Review; ACUTE PROMYELOCYTIC LEUKEMIA; RNA-POLYMERASE-II; CREB-BINDING-PROTEIN; RETINOIC ACID; DNA-DAMAGE; TELOMERE LENGTH; BODY FORMATION; RAR-ALPHA; SITES; TRANSCRIPTION;
D O I
10.2741/3302
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Promyelocytic leukaemia nuclear bodies (PML NBs) are found within the nucleus of mammalian cells, and are formed from the constituent proteins PML and Sp100. Numbering between 10 and 30 per cell, they are an obvious feature of the nuclear landscape, yet their functions have still to be unambiguously defined. In the mammalian nucleus, compartmentalization of functions is apparent, as reflected in the wide-range of other nuclear compartments that can be identified. These include nucleoli, transcription foci, splicing speckles, chromosomal topological markers such as centromeres and telomeres, the nuclear boundary, and the nucleoplasm itself. Quantification of the otherwise qualitative observations of relationships between mammalian nuclear compartments is essential for a complete understanding of nuclear processes. Here we describe some of the interesting known associations between PML NBs and other nuclear compartments, and comment upon their implications for PML NB function.
引用
收藏
页码:1182 / U7
页数:16
相关论文
共 106 条
[1]   The promyelocytic leukemia gene product (PML) forms stable complexes with the retinoblastoma protein [J].
Alcalay, M ;
Tomassoni, L ;
Colombo, E ;
Stoldt, S ;
Grignani, F ;
Fagioli, M ;
Szekely, L ;
Helin, K ;
Pelicci, PG .
MOLECULAR AND CELLULAR BIOLOGY, 1998, 18 (02) :1084-1093
[2]   Cajal body number and nucleolar size correlate with the cell body mass in human sensory ganglia neurons [J].
Berciano, Maria T. ;
Novell, Mariona ;
Villagra, Nuria T. ;
Casafont, Inigo ;
Bengoechea, Rocio ;
Val-Bernal, J. Fernado ;
Lafarga, Miguel .
JOURNAL OF STRUCTURAL BIOLOGY, 2007, 158 (03) :410-420
[3]   PML regulates p53 stability by sequestering Mdm2 to the nucleolus [J].
Bernardi, R ;
Scaglioni, PP ;
Bergmann, S ;
Horn, HF ;
Vousden, KH ;
Pandolfi, PP .
NATURE CELL BIOLOGY, 2004, 6 (07) :665-672
[4]   Structure, dynamics and functions of promyelocytic leukaemia nuclear bodies [J].
Bernardi, Rosa ;
Pandolfi, Pier Paolo .
NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2007, 8 (12) :1006-1016
[5]   Role for centromeric heterochrornatin and PML nuclear bodies in the cellular response to foreign DNA [J].
Bishop, CL ;
Ramalho, M ;
Nadkarni, N ;
Kong, WM ;
Higgins, CF ;
Krauzewicz, N .
MOLECULAR AND CELLULAR BIOLOGY, 2006, 26 (07) :2583-2594
[6]   Telomere length, stem cells and aging [J].
Blasco, Maria A. .
NATURE CHEMICAL BIOLOGY, 2007, 3 (10) :640-649
[7]  
Boddy MN, 1996, ONCOGENE, V13, P971
[8]   Promyelocytic leukemia nuclear bodies are predetermined processing sites for damaged DNA [J].
Boe, Stig Ove ;
Haave, Marte ;
Jul-Larsen, Asne ;
Grudic, Amra ;
Bjerkvig, Rolf ;
Lonning, Per Eystein .
JOURNAL OF CELL SCIENCE, 2006, 119 (16) :3284-3295
[9]   Promyelocytic leukemia (PML) nuclear bodies are protein structures that do not accumulate RNA [J].
Boisvert, FM ;
Hendzel, MJ ;
Bazett-Jones, DP .
JOURNAL OF CELL BIOLOGY, 2000, 148 (02) :283-292
[10]   The transcription coactivator CBP is a dynamic component of the promyelocytic leukemia nuclear body [J].
Boisvert, FM ;
Kruhlak, MJ ;
Box, AK ;
Hendzel, MJ ;
Bazett-Jones, DP .
JOURNAL OF CELL BIOLOGY, 2001, 152 (05) :1099-1106