Antibodies in HIV-1 Vaccine Development and Therapy

被引：363

作者：

Klein, Florian ^{[1
]}

Mouquet, Hugo ^{[2
]}

Dosenovic, Pia ^{[1
]}

Scheid, Johannes F. ^{[1
]}

Scharf, Louise ^{[3
]}

Nussenzweig, Michel C. ^{[1
,4
]}

机构：

[1] Rockefeller Univ, Lab Mol Immunol, New York, NY 10065 USA

[2] Inst Pasteur, Dept Immunol, Lab Humoral Response Pathogens, Paris, France

[3] CALTECH, Div Biol, Pasadena, CA 91125 USA

[4] Rockefeller Univ, Howard Hughes Med Inst HHMI, New York, NY 10065 USA

来源：

SCIENCE | 2013年 / 341卷 / 6151期

基金：

瑞典研究理事会;

关键词：

HUMAN MONOCLONAL-ANTIBODIES; BROADLY NEUTRALIZING ANTIBODIES; MUCOSAL SHIV CHALLENGE; B-CELL RESPONSES; 3-DIMENSIONAL STRUCTURE; CONFORMATIONAL EPITOPE; POTENT NEUTRALIZATION; IMMUNOGEN DESIGN; PASSIVE TRANSFER; STRUCTURAL BASIS;

D O I：

10.1126/science.1241144

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Despite 30 years of study, there is no HIV-1 vaccine and, until recently, there was little hope for a protective immunization. Renewed optimism in this area of research comes in part from the results of a recent vaccine trial and the use of single-cell antibody-cloning techniques that uncovered naturally arising, broad and potent HIV-1-neutralizing antibodies (bNAbs). These antibodies can protect against infection and suppress established HIV-1 infection in animal models. The finding that these antibodies develop in a fraction of infected individuals supports the idea that new approaches to vaccination might be developed by adapting the natural immune strategies or by structure-based immunogen design. Moreover, the success of passive immunotherapy in small-animal models suggests that bNAbs may become a valuable addition to the armamentarium of drugs that work against HIV-1.

引用

页码：1199 / 1204

页数：6

共 105 条

[1] Cell-Cell Transmission Enables HIV-1 to Evade Inhibition by Potent CD4bs Directed Antibodies [J].

Abela, Irene A. ;

Berlinger, Livia ;

Schanz, Merle ;

Reynell, Lucy ;

Guenthard, Huldrych F. ;

Rusert, Peter ;

Trkola, Alexandra .

PLOS PATHOGENS, 2012, 8 (04)

[2] The role of antibody polyspecificity and lipid reactivity in binding of broadly neutralizing anti-HIV-1 envelope human monoclonal antibodies 2F5 and 4E10 to glycoprotein 41 membrane proximal envelope epitopes [J].

Alam, S. Munir ;

McAdams, Mildred ;

Boren, David ;

Rak, Michael ;

Scearce, Richard M. ;

Gao, Feng ;

Camacho, Zenaido T. ;

Gewirth, Daniel ;

Kelsoe, Garnett ;

Chen, Pojen ;

Haynes, Barton F. .

JOURNAL OF IMMUNOLOGY, 2007, 178 (07) :4424-4435

[3] Role of HIV membrane in neutralization by two broadly neutralizing antibodies [J].

Alam, S. Munir ;

Morelli, Marco ;

Dennison, S. Moses ;

Liao, Hua-Xin ;

Zhang, Ruijun ;

Xia, Shi-Mao ;

Rits-Volloch, Sophia ;

Sun, Li ;

Harrison, Stephen C. ;

Haynes, Barton F. ;

Chen, Bing .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (48) :20234-20239

[4] 3-DIMENSIONAL STRUCTURE OF IMMUNOGLOBULINS [J].

AMZEL, LM ;

POLJAK, RJ .

ANNUAL REVIEW OF BIOCHEMISTRY, 1979, 48 :961-997

[5] Human neutralizing monoclonal antibodies of the IgG1 subtype protect against mucosal simian-human immunodeficiency virus infection [J].

Baba, TW ;

Liska, V ;

Hofmann-Lehmann, R ;

Vlasak, J ;

Xu, WD ;

Ayehunie, S ;

Cavacini, LA ;

Posner, MR ;

Katinger, H ;

Stiegler, G ;

Bernacky, BJ ;

Rizvi, TA ;

Schmidt, R ;

Hill, LR ;

Keeling, ME ;

Lu, YC ;

Wright, JE ;

Chou, TC ;

Ruprecht, RM .

NATURE MEDICINE, 2000, 6 (02) :200-206

[6] Disseminated and sustained HIV infection in CD34+ cord blood cell-transplanted Rag2-/-γc-/- mice [J].

Baenziger, Stefan ;

Tussiwand, Roxane ;

Schlaepfer, Erika ;

Mazzucchelli, Luca ;

Heikenwalder, Mathias ;

Kurrer, Michael O. ;

Behnke, Silvia ;

Frey, Joachim ;

Oxenius, Annette ;

Joller, Helen ;

Aguzzi, Adriano ;

Manz, Markus G. ;

Speck, Roberto F. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (43) :15951-15956

[7] Antibody-based protection against HIV infection by vectored immunoprophylaxis [J].

Balazs, Alejandro B. ;

Chen, Joyce ;

Hong, Christin M. ;

Rao, Dinesh S. ;

Yang, Lili ;

Baltimore, David .

NATURE, 2012, 481 (7379) :81-U88

[8] Affinity dependence of the B cell response to antigen: A threshold, a ceiling, and the importance of off-rate [J].

Batista, FD ;

Neuberger, MS .

IMMUNITY, 1998, 8 (06) :751-759

[9] Immunization with HIV-1 gp41 Subunit Virosomes Induces Mucosal Antibodies Protecting Nonhuman Primates against Vaginal SHIV Challenges [J].

Bomsel, Morgane ;

Tudor, Daniela ;

Drillet, Anne-Sophie ;

Alfsen, Annette ;

Ganor, Yonatan ;

Roger, Marie-Gaelle ;

Mouz, Nicolas ;

Amacker, Mario ;

Chalifour, Anick ;

Diomede, Lorenzo ;

Devillier, Gilles ;

Cong, Zhe ;

Wei, Qiang ;

Gao, Hong ;

Qin, Chuan ;

Yang, Gui-Bo ;

Zurbriggen, Rinaldo ;

Lopalco, Lucia ;

Fleury, Sylvain .

IMMUNITY, 2011, 34 (02) :269-280

[10] Antibody-Dependent Cellular Cytotoxicity-Mediating Antibodies from an HIV-1 Vaccine Efficacy Trial Target Multiple Epitopes and Preferentially Use the VH1 Gene Family [J].

Bonsignori, Mattia ;

Pollara, Justin ;

Moody, M. Anthony ;

Alpert, Michael D. ;

Chen, Xi ;

Hwang, Kwan-Ki ;

Gilbert, Peter B. ;

Huang, Ying ;

Gurley, Thaddeus C. ;

Kozink, Daniel M. ;

Marshall, Dawn J. ;

Whitesides, John F. ;

Tsao, Chun-Yen ;

Kaewkungwal, Jaranit ;

Nitayaphan, Sorachai ;

Pitisuttithum, Punnee ;

Rerks-Ngarm, Supachai ;

Kim, Jerome H. ;

Michael, Nelson L. ;

Tomaras, Georgia D. ;

Montefiori, David C. ;

Lewis, George K. ;

DeVico, Anthony ;

Evans, David T. ;

Ferrari, Guido ;

Liao, Hua-Xin ;

Haynes, Barton F. .

JOURNAL OF VIROLOGY, 2012, 86 (21) :11521-11532

← 1 2 3 4 5 6 7 8 9 10 →