Genomic insights into the emergence and spread of antimicrobial-resistant bacterial pathogens

被引：276

作者：

Baker, Stephen ^{[1
,2
,3
]}

Thomson, Nicholas ^{[4
,5
]}

Weill, Francois-Xavier ^{[6
]}

Holt, Kathryn E. ^{[5
,7
]}

机构：

[1] Univ Oxford, Clin Res Unit, Ho Chi Minh City, Vietnam

[2] Univ Oxford, Ctr Trop Med & Global Hlth, Oxford, England

[3] Univ Cambridge, Dept Med, Cambridge, England

[4] Wellcome Trust Sanger Inst, Cambridge, England

[5] London Sch Hyg & Trop Med, London, England

[6] Inst Pasteur, Paris, France

[7] Univ Melbourne, Mol Sci & Biotechnol Inst Bio21, Dept Biochem & Mol Biol, Parkville, Vic, Australia

来源：

SCIENCE | 2018年 / 360卷 / 6390期

基金：

英国惠康基金;

关键词：

SALMONELLA-TYPHIMURIUM DT104; STAPHYLOCOCCUS-AUREUS; ANTIBIOTIC-RESISTANCE; MYCOBACTERIUM-TUBERCULOSIS; NEISSERIA-GONORRHOEAE; DRUG-RESISTANCE; EVOLUTION; DISSEMINATION; TRANSMISSION; PLASMIDS;

D O I：

10.1126/science.aar3777

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Whole-genome sequencing (WGS) has been vital for revealing the rapid temporal and spatial evolution of antimicrobial resistance (AMR) in bacterial pathogens. Some antimicrobialresistant pathogens have outpaced us, with untreatable infections appearing in hospitals and the community. However, WGS has additionally provided us with enough knowledge to initiate countermeasures. Although we cannot stop bacterial adaptation, the predictability of many evolutionary processes in AMR bacteria offers us an opportunity to channel them using new control strategies. Furthermore, by usingWGS for coordinating surveillance and to create a more fundamental understanding of the outcome of antimicrobial treatment and AMR mechanisms, we can use current and future antimicrobials more effectively and aim to extend their longevity.

引用

页码：733 / 738

页数：6

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