Complete response of 7 years' duration after chemoradiotherapy followed by gefitinib in a patient with intramedullary spinal cord metastasis from lung adenocarcinoma

被引：10

作者：

Hata, Yoshinobu ^{[1
]}

Takai, Yujiro ^{[2
]}

Takahashi, Hiroshi ^{[3
]}

Takagi, Keigo ^{[1
]}

Isobe, Kazutoshi ^{[2
]}

Hasegawa, Chikako ^{[4
]}

Shibuya, Kazutoshi ^{[3
]}

Goto, Hidenori ^{[1
]}

Tamaki, Kazuyoshi ^{[1
]}

Sato, Fumitomo ^{[1
]}

Otsuka, Hajime ^{[1
]}

机构：

[1] Toho Univ, Omori Med Ctr, Dept Chest Surg, Tokyo 1438541, Japan

[2] Toho Univ, Omori Med Ctr, Dept Resp Med, Tokyo 1438541, Japan

[3] Toho Univ, Omori Med Ctr, Dept Orthoped Surg, Tokyo 1438541, Japan

[4] Toho Univ, Omori Med Ctr, Dept Surg Pathol, Tokyo 1438541, Japan

来源：

JOURNAL OF THORACIC DISEASE | 2013年 / 5卷 / 02期

关键词：

Intramedullary spinal cord metastasis; lung cancer; gefitinib; EGFR; magnetic resonance imaging; positron-emission tomography; CLINICAL-FEATURES; COLON-CANCER; SYSTEM;

D O I：

10.3978/j.issn.2072-1439.2012.12.09

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Intramedullary spinal cord metastasis is a rare but serious complication which causes rapid progression of neurological deficits. Here we report a 35-year-old man presenting with increasing leg pain and gait disturbance, 8 months after surgery for lung adenocarcinoma. Spinal magnetic resonance imaging revealed an intramedullary tumor at the Th7/8 level. Radiotherapy at 35 Gy resulted in transient symptomatic improvement, but during chemotherapy with vinorelbine and cisplatin, symptoms worsened again. Gefitinib was then administered; the patient improved after 2 weeks and has now maintained a complete response for 7 years.

引用

页码：E65 / E67

页数：3

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