Gastric cancer

被引：1633

作者：

Van Cutsem, Eric ^{[1
]}

Sagaert, Xavier ^{[2
]}

Topal, Baki ^{[3
]}

Haustermans, Karin ^{[4
]}

Prenen, Hans

机构：

[1] Univ Hosp Gasthuisberg Leuven, Dept Gastroenterol Digest Oncol, Leuven, Belgium

[2] Univ Hosp Gasthuisberg Leuven, Dept Pathol, Leuven, Belgium

[3] Univ Hosp Gasthuisberg Leuven, Dept Abdominal Surg, Leuven, Belgium

[4] Univ Hosp Gasthuisberg Leuven, Dept Radiat Oncol, Leuven, Belgium

来源：

LANCET | 2016年 / 388卷 / 10060期

关键词：

RANDOMIZED PHASE-III; GASTROESOPHAGEAL JUNCTION ADENOCARCINOMA; EPSTEIN-BARR-VIRUS; HELICOBACTER-PYLORI; DOUBLE-BLIND; OPEN-LABEL; PLUS CISPLATIN; 1ST-LINE THERAPY; SUPPORTIVE CARE; INTESTINAL-TYPE;

D O I：

10.1016/S0140-6736(16)30354-3

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Gastric cancer is one of the leading causes of cancer-related death worldwide. Many patients have inoperable disease at diagnosis or have recurrent disease after resection with curative intent. Gastric cancer is separated anatomically into true gastric adenocarcinomas and gastro-oesophageal-junction adenocarcinomas, and histologically into diffuse and intestinal types. Gastric cancer should be treated by teams of experts from different disciplines. Surgery is the only curative treatment. For locally advanced disease, adjuvant or neoadjuvant therapy is usually implemented in combination with surgery. In metastatic disease, outcomes are poor, with median survival being around 1 year. Targeted therapies, such as trastuzumab, an antibody against HER2 (also known as ERBB2), and the VEGFR-2 antibody ramucirumab, have been introduced. In this Seminar, we present an update of the causes, classification, diagnosis, and treatment of gastric cancer.

引用

页码：2654 / 2664

页数：11

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