Electrospun polyacrylonitrile/cellulose acetate/MIL-125/TiO2composite nanofibers as an efficient photocatalyst and anticancer drug delivery system

In the present study, the various amounts of MIL-125-NH(2)metal organic framework (MOF)/TiO(2)nanocomposite were incorporated into the polyacrylonitrile (PAN)/cellulose acetate (CA) (8:2 w/w) nanofibers. The performance of MIL-125-NH2/TiO(2)nanocomposite loaded-PAN/CA nanofibers was investigated for the removal of Doxorubicin HCl (DOX) and Cr(VI) during photocatalysis/adsorption method, controlled release of DOX and MCF-7 breast cancer cells death in vitro. The synthesized MIL-125-NH2MOF, TiO2, MOF/TiO(2)and MOF/TiO(2)loaded-nanofibers were characterized using X-ray diffraction, scanning electron microscopy, Fourier transform infrared, transmission electron microscopy, and Brunaure-Emmet-Teller analysis. The effect of MOF to TiO(2)weight ratio, MOF/TiO(2)content, pH, contact time, catalyst dosage, and initial concentrations of DOX and Cr(VI) solutions was evaluated on the photocatalytic removal of DOX molecules and Cr(VI) ions from aqueous solutions. The maximum monolayer adsorption capacity of synthesized PAN/CA//MIL-125-NH2/TiO(2)nanofibers was found to be 244.5 and 273.3 mg g(-1)for DOX and Cr(VI) sorption, respectively. The reusability of nanofibers was also examined after five runs. The sustained release of DOX from PAN/CA/MIL-125-NH2/TiO(2)was obtained during 7 days. The maximum MCF-7 cells death percentage was found to be 68% in the presence of PAN/CA/MIL-125-NH2/TiO(2)nanofibers.