S100A7: A rAMPing up AMP molecule in psoriasis

被引：34
作者：
D'Amico, Fabio [1 ]
Skarmoutsou, Evangelia [1 ]
Granata, Mariagrazia [1 ]
Trovato, Chiara [1 ]
Rossi, Giulio Antonino [1 ]
Mazzarino, Maria Clorinda [1 ]
机构：
[1] Univ Catania, Dept Biomed & Biotechnol Sci, Via Androne 83, I-95124 Catania, Italy
来源：
CYTOKINE & GROWTH FACTOR REVIEWS | 2016年 / 32卷
关键词：
S100A7; Psoriasin; Keratinocyte; Psoriasis; CALCIUM-BINDING PROTEINS; EPIDERMAL DIFFERENTIATION COMPLEX; HUMAN KERATINOCYTES; TERMINAL DIFFERENTIATION; BREAST-CANCER; IN-VITRO; ANTIMICROBIAL PEPTIDES; KOEBNERISIN S100A15; CUTANEOUS INNATE; UP-REGULATION;
D O I：
10.1016/j.cytogfr.2016.01.002
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
S100A7 (psoriasin), an EF-hand type calcium binding protein localized in epithelial cells, regulates cell proliferation and differentiation. An S100A7 overexpression may occur in response to inflammatory stimuli, such in psoriasis, a chronic inflammatory autoimmune-mediated skin disease. Increasing evidence suggests that S100A7 plays critical roles in amplifying the inflammatory process in psoriatic skin, perpetuating the disease phenotype. This review will discuss the interactions between S100A7 and cytokines in psoriatic skin. Furthermore, we will focus our discussion on regulation and functions of S100A7 in psoriasis. Finally, we will discuss the possible use of S100A7 as therapeutic target in psoriasis. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码：97 / 104
页数：8
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