Uniformity in clinical and HLA-DR status regardless of age and gender within fulminant type 1 diabetes

被引：21

作者：

Imagawa, Akihisa ^{[1
]}

Hanafusa, Toshiaki ^{[1
]}

Iwahashi, Hiromi ^{[2
]}

Uchigata, Yasuko ^{[3
]}

Kanatsuka, Azuma ^{[4
]}

Kawasaki, Eiji ^{[5
]}

Kobayashi, Tetsuro ^{[6
]}

Shimada, Akira ^{[7
]}

Shimizu, Ikki ^{[8
]}

Maruyama, Taro ^{[9
]}

Makino, Hideichi ^{[10
]}

机构：

[1] Osaka Med Coll, Dept Internal Med 1, Takatsuki, Osaka 5698686, Japan

[2] Osaka Univ, Grad Sch Med, Dept Metab Med, Suita, Osaka, Japan

[3] Tokyo Womens Med Univ, Sch Med, Ctr Diabet, Tokyo, Japan

[4] Chiba Cent Med Ctr, Ctr Diabet, Chiba, Japan

[5] Nagasaki Univ Hosp Med & Dent, Dept Metab Diabetes & Clin Nutr, Nagasaki, Japan

[6] Univ Yamanashi, Interdisciplinary Grad Sch Med & Engn, Dept Internal Med 3, Tamaho, Yamanashi, Japan

[7] Keio Univ, Sch Med, Dept Internal Med, Tokyo, Japan

[8] Ehime Prefectural Cent Hosp, Matsuyama, Ehime, Japan

[9] Social Insurance Saitamachuo Hosp, Dept Internal Med, Saitama, Japan

[10] Ehime Univ, Sch Med, Dept Lab Med, Toon, Japan

来源：

DIABETES RESEARCH AND CLINICAL PRACTICE | 2008年 / 82卷 / 02期

关键词：

Idiopathic; Phenotype; Child; Pubertal; Pregnancy;

D O I：

10.1016/j.diabres.2008.08.003

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

To clarify the detailed clinical features and HLA subtype in the patients with fulminant type 1 diabetes, we investigated consecutive 250 case records registered to the committee of the Japan Diabetes Society between 2000/7/15 and 2006/6/30. After the classification with age at onset or gender, clinical data and HLA DR were evaluated. As a result, the prevalence of male patients, BMI, HbA(1c) and ALT levels at the onset increased significantly according to the elder quartile, but no other data showed any significant difference. Only age at onset and blood glucose level were significantly higher in male patients than in female patients without pregnancy by multivariate analysis. The distribution of HLA DR was not different in any subtype by gender or age at onset. Our present study revealed common feature in clinical and HLA-DR status regardless of age and gender within fulminant type 1 diabetes except pregnant women. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

引用

页码：233 / 237

页数：5

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