Photoresponsive, Water-Soluble Supramolecular Dendronized Polymer with Specific Lysosome-Targetable Bioimaging Application in Living Cells

被引：14
|
作者：
Li, Hang [1 ]
Wu, Jie [2 ]
Yin, Jia-Fu [1 ]
Wang, Huan [1 ]
Wu, Yongquan [2 ]
Kuang, Gui-Chao [1 ,3 ]
机构：
[1] Cent S Univ, State Key Lab Power Met, Lushan South Rd 932, Changsha 410083, Hunan, Peoples R China
[2] Gannan Normal Univ, Sch Chem & Chem Engn, Key Lab Organopharmaceut Chem, Ganzhou 341000, Jiangxi, Peoples R China
[3] Peking Univ, Beijing Natl Lab Mol Sci, Key Lab Polymer Chem & Phys,Minister Educ, Ctr Soft Matter Sci & Engn,Coll Chem & Mol Engn, Beijing 100871, Peoples R China
来源：
MACROMOLECULAR RAPID COMMUNICATIONS | 2019年 / 40卷 / 03期
基金：
中国国家自然科学基金;
关键词：
BODIPY; host-guest interactions; lysosome targetable bioimaging; supramolecular dendronized polymers; BODIPY; DERIVATIVES; ARCHITECTURES; ASSEMBLIES; CONVERSION; 1D;
D O I：
10.1002/marc.201800714
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
A novel photoresponsive, water-soluble supramolecular dendronized polymer (SDP) is prepared through a gamma -cyclodextrin (gamma -CD)-coumarin host-guest interaction. The supramolecular formation, photoresponsive process, and fluorescence properties are investigated by nuclear magnetic resonance (NMR) techniques and spectrometric measurements. Upon different-wavelength light irradiation, this supramolecular polymer undergoes noncovalent polymer and covalent polymer conversion due to coumarin cycloaddition and cleavage reactions. In addition, SDP for bioimaging in Michigan Cancer Foundation-7 (MCF-7) cells is performed and results show that the obtained SDP has good biocompatibility and is lysosome-targetable. This research enriches the field of supramolecular dendrimers and the photo-stimulation response material may have application prospects in organelle-targeting applications.
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页数：5
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