Curcumin and its derivatives: Moderate inhibitors of acetylcholinesterase, butyrylcholinesterase and trypsin

被引：33

作者：

Abbasi, M. A. ^{[1
]}

Ilyas, M. ^{[1
]}

Aziz-ur-Rehman ^{[1
]}

Sonia, A. ^{[1
]}

Shahwar, D. ^{[1
]}

Raza, M. A. ^{[2
]}

Khan, K. M. ^{[3
]}

Ashraf, M. ^{[4
]}

Afzal, I. ^{[5
]}

Ambreen, N. ^{[3
]}

机构：

[1] Govt Coll Univ, Dept Chem, Lahore 54000, Pakistan

[2] Univ Gujrat, Dept Chem, Gujrat, Pakistan

[3] Univ Karachi, HEJ Res Inst Chem, Int Ctr Chem & Biol Sci, Karachi 75270, Pakistan

[4] Islamia Univ Bahawalpur, Dept Biochem & Biotechnol, Bahawalpur 63100, Pakistan

[5] Islamia Univ Bahawalpur, Dept Pharm, Bahawalpur 63100, Pakistan

来源：

SCIENTIA IRANICA | 2012年 / 19卷 / 06期

关键词：

Curcumin; Synthetic derivatives; Acetylcholinesterase; Butyrylcholinesterase; Lipoxygenase; Trypsin; DNA ADDUCT FORMATION;

D O I：

10.1016/j.scient.2012.10.014

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Curcumin, a polyphenol yellow orange pigment present in Indian spice "turmeric", is a member of the ginger family (Zingiberaceae). The extract of turmeric was obtained by using soxhlet apparatus at 45-55 degrees C, using methanol as solvent and then curcumin was isolated from methanolic extract by column chromatography. In the present study, a series of four new derivatives of curcumin (3a-d) were synthesized by reacting curcumin (1) with different alkyl halides (2a-d) using DMF and lithium hydride. The structures of natural curcumin and its synthetic derivatives were confirmed with the help of their H-1-NMR spectra and all these were screened against acetylcholinesterase, butyrylcholinesterase, lipoxygenase and trypsin enzymes. Curcumin and its derivatives exhibited moderate inhibitory potential against all aforesaid enzymes. (C) 2012 Sharif University of Technology. Production and hosting by Elsevier B.V. All rights reserved.

引用

页码：1580 / 1583

页数：4

共 17 条

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