ATRX The case of a peculiar chromatin remodeler

被引：56
作者：
Ratnakumar, Kajan
Bernstein, Emily [1 ]
机构：
[1] Mt Sinai Sch Med, Dept Oncol Sci, New York, NY USA
来源：
EPIGENETICS | 2013年 / 8卷 / 01期
关键词：
ATRX; histone variants; telomeres; alpha-globin; macroH2A and H3.3; MENTAL-RETARDATION SYNDROME; X SYNDROME PROTEIN; ALPHA-THALASSEMIA; ADD DOMAIN; HISTONE CHAPERONE; FREQUENT ATRX; STEM-CELLS; MUTATIONS; DAXX; H3.3;
D O I：
10.4161/epi.23271
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The SWI/SNF-like chromatin remodeler ATRX has recently garnered renewed attention. ATRX mutations were first identified in patients bearing the syndrome after which it is named, alpha thalassemia/mental retardation, X-linked. While ATRX has long been implicated in transcriptional regulation through multiple mechanisms, recent studies have identified a role for ATRX in the regulation of histone variant deposition. In addition, current reports describe ATRX to be mutated at high percentages in multiple tumor types, suggestive of a potential 'driver' role in cancer. Here we discuss the numerous and seemingly diverse roles for ATRX in transcriptional regulation and histone deposition and suggest that ATRX's effects are mediated by its regulation of histones within the chromatin template.
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页码：3 / 9
页数：7
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