pH-responsive amphiphilic hydrogel networks with IPN structure: A strategy for controlled drug

被引：70

作者：

Liu, YY ^{[1
]}

Fan, XD ^{[1
]}

Wei, BR ^{[1
]}

Si, QF ^{[1
]}

Chen, WX ^{[1
]}

Sun, L ^{[1
]}

机构：

[1] Northwestern Polytech Univ, Sch Sci, Dept Appl Chem, Xian 710072, Peoples R China

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2006年 / 308卷 / 1-2期

关键词：

amphiphilic hydrogel; interpenetrating polymer networks; pH-sensitivity; the controlled release;

D O I：

10.1016/j.ijpharm.2005.10.013

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A pH-responsive amphiphilic hydrogel with interpenetrating polymer networks (IPN) structure for controlled drug release was proposed. The IPN was constructed with hydrophilic poly(acrylic acid) (PAA) and hydrophobic poly(butyl acrylate) (PBA). Using drug iV-acetyl-5-methoxytryptamine (melatonin, MEL) as a model molecule, the controlled drug release behaviors of the IPN were investigated. It is found that not only the release of MEL from the IPN can respond to change in pH, but also the presence of hydrophobic network can overcome disadvantageous burst effect of hydrophilic network. This may be a result of hydrophobic aggregation encapsulating MEL molecules. (c) 2005 Elsevier B.V. All rights reserved.

引用

页码：205 / 209

页数：5

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