The checkpoint inhibitor TIGIT limits antitumor and antiviral CD8+ T cell responses

被引：40

作者：

Johnston, Robert J. ^{[1
]}

Yu, Xin ^{[1
]}

Grogan, Jane L. ^{[1
]}

机构：

[1] Genentech Inc, Dept Canc Immunol, San Francisco, CA 94080 USA

来源：

ONCOIMMUNOLOGY | 2015年 / 4卷 / 09期

关键词：

TIGIT; CD226; PD1; cancer immunotherapy; virus; antibodies; PVR;

D O I：

10.1080/2162402X.2015.1036214

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Success in eliciting tumor rejection by therapeutic blockade of T cell checkpoint inhibitors, such as PD-1/PD-L1 and CTLA-4, has spurred re-evaluation of additional receptors that regulate antitumor responses. Here we summarize our recent studies characterizing the role of co-inhibitory receptor TIGIT in antitumor and other chronic CD8(+) T cell responses.

引用

页码：1 / 2

页数：2

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