The biological function and the regulatory roles of wild-type p53-induced phosphatase 1 in immune system
被引:16
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作者:
Shi, Lu
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Chinese Acad Sci, Inst Zool, State Key Lab Membrane Biol, Beichen West Rd 1-5, Beijing 100101, Peoples R ChinaChinese Acad Sci, Inst Zool, State Key Lab Membrane Biol, Beichen West Rd 1-5, Beijing 100101, Peoples R China
Shi, Lu
[1
]
Tian, Qianchuan
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Chinese Acad Sci, Inst Zool, State Key Lab Membrane Biol, Beichen West Rd 1-5, Beijing 100101, Peoples R China
Univ Chinese Acad Sci, Beijing, Peoples R ChinaChinese Acad Sci, Inst Zool, State Key Lab Membrane Biol, Beichen West Rd 1-5, Beijing 100101, Peoples R China
Tian, Qianchuan
[1
,2
]
Feng, Chang
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Chinese Acad Sci, Inst Zool, State Key Lab Membrane Biol, Beichen West Rd 1-5, Beijing 100101, Peoples R China
Univ Chinese Acad Sci, Beijing, Peoples R ChinaChinese Acad Sci, Inst Zool, State Key Lab Membrane Biol, Beichen West Rd 1-5, Beijing 100101, Peoples R China
Feng, Chang
[1
,2
]
Zhang, Peng
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Chinese Acad Sci, Inst Zool, State Key Lab Membrane Biol, Beichen West Rd 1-5, Beijing 100101, Peoples R China
Univ Chinese Acad Sci, Beijing, Peoples R ChinaChinese Acad Sci, Inst Zool, State Key Lab Membrane Biol, Beichen West Rd 1-5, Beijing 100101, Peoples R China
Zhang, Peng
[1
,2
]
Zhao, Yong
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Chinese Acad Sci, Inst Zool, State Key Lab Membrane Biol, Beichen West Rd 1-5, Beijing 100101, Peoples R China
Univ Chinese Acad Sci, Beijing, Peoples R China
Chinese Acad Sci, Inst Stem Cell & Regenerat, Beijing, Peoples R ChinaChinese Acad Sci, Inst Zool, State Key Lab Membrane Biol, Beichen West Rd 1-5, Beijing 100101, Peoples R China
Zhao, Yong
[1
,2
,3
]
机构:
[1] Chinese Acad Sci, Inst Zool, State Key Lab Membrane Biol, Beichen West Rd 1-5, Beijing 100101, Peoples R China
[2] Univ Chinese Acad Sci, Beijing, Peoples R China
[3] Chinese Acad Sci, Inst Stem Cell & Regenerat, Beijing, Peoples R China
Wild-type p53-induced phosphatase 1 (WIP1) belongs to the protein phosphatase 2C (PP2C) family and is a mammalian serine/threonine specific protein phosphatase to dephosphorylate numerous signaling molecules. Mammalian WIP1 regulates a wide array of targeting molecules and plays key regulatory roles in many cell processes such as DNA damage and repair, cell proliferation, differentiation, apoptosis, and senescence. WIP1 promotes the formation and development of tumors as an oncogene and a negative regulator of p53. It is also involved in the regulation of aging, neurological diseases and immune diseases. Recent studies demonstrated the critical roles of WIP1 in the differentiation and function of immune cells including T cells, neutrophils and macrophages. In the present manuscript, we briefly summarized the expression patterns, biological function and the target molecules and signal pathways of WIP1 and mainly discussed the latest advances on the regulatory effects of WIP1 in the immune system. WIP1 may be a potential target molecule to treat cancers and immune diseases such as allergic asthma.
机构:
Univ Ulsan, Coll Med, Dept Pathol, Asan Med Ctr, Seoul 138736, South Korea
Univ Ulsan, Coll Med, Asan Inst Life Sci, Asan Med Ctr, Seoul 138736, South KoreaUniv Ulsan, Coll Med, Dept Pathol, Asan Med Ctr, Seoul 138736, South Korea
Park, Ji-Young
Song, Ji-Young
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Univ Ulsan, Coll Med, Dept Pathol, Asan Med Ctr, Seoul 138736, South Korea
Univ Ulsan, Coll Med, Asan Inst Life Sci, Asan Med Ctr, Seoul 138736, South KoreaUniv Ulsan, Coll Med, Dept Pathol, Asan Med Ctr, Seoul 138736, South Korea
Song, Ji-Young
Kim, Hyun Mi
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Univ Ulsan, Coll Med, Dept Pathol, Asan Med Ctr, Seoul 138736, South Korea
Univ Ulsan, Coll Med, Asan Inst Life Sci, Asan Med Ctr, Seoul 138736, South KoreaUniv Ulsan, Coll Med, Dept Pathol, Asan Med Ctr, Seoul 138736, South Korea
Kim, Hyun Mi
Han, Hye-Sook
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Univ Ulsan, Coll Med, Dept Pathol, Asan Med Ctr, Seoul 138736, South Korea
Univ Ulsan, Coll Med, Asan Inst Life Sci, Asan Med Ctr, Seoul 138736, South KoreaUniv Ulsan, Coll Med, Dept Pathol, Asan Med Ctr, Seoul 138736, South Korea
Han, Hye-Sook
Seol, Hyang Sook
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Univ Ulsan, Coll Med, Dept Pathol, Asan Med Ctr, Seoul 138736, South Korea
Univ Ulsan, Coll Med, Asan Inst Life Sci, Asan Med Ctr, Seoul 138736, South KoreaUniv Ulsan, Coll Med, Dept Pathol, Asan Med Ctr, Seoul 138736, South Korea
Seol, Hyang Sook
Jang, Se Jin
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Univ Ulsan, Coll Med, Dept Pathol, Asan Med Ctr, Seoul 138736, South KoreaUniv Ulsan, Coll Med, Dept Pathol, Asan Med Ctr, Seoul 138736, South Korea
Jang, Se Jin
Choi, Jene
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Univ Ulsan, Coll Med, Dept Pathol, Asan Med Ctr, Seoul 138736, South KoreaUniv Ulsan, Coll Med, Dept Pathol, Asan Med Ctr, Seoul 138736, South Korea
Choi, Jene
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY,
2012,
44
(06):
: 896
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904