The biological function and the regulatory roles of wild-type p53-induced phosphatase 1 in immune system

被引:16
|
作者
Shi, Lu [1 ]
Tian, Qianchuan [1 ,2 ]
Feng, Chang [1 ,2 ]
Zhang, Peng [1 ,2 ]
Zhao, Yong [1 ,2 ,3 ]
机构
[1] Chinese Acad Sci, Inst Zool, State Key Lab Membrane Biol, Beichen West Rd 1-5, Beijing 100101, Peoples R China
[2] Univ Chinese Acad Sci, Beijing, Peoples R China
[3] Chinese Acad Sci, Inst Stem Cell & Regenerat, Beijing, Peoples R China
关键词
Gene expression; immunity; neutrophils; signaling pathways; Th9; cells; WIP1; WIP1; PHOSPHATASE; TUMOR-SUPPRESSOR; ONCOGENIC PROPERTIES; PROTEIN PHOSPHATASE; IONIZING-RADIATION; GENOTOXIC STRESS; P38; MAPK; PPM1D; P53; INHIBITION;
D O I
10.1080/08830185.2020.1795153
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Wild-type p53-induced phosphatase 1 (WIP1) belongs to the protein phosphatase 2C (PP2C) family and is a mammalian serine/threonine specific protein phosphatase to dephosphorylate numerous signaling molecules. Mammalian WIP1 regulates a wide array of targeting molecules and plays key regulatory roles in many cell processes such as DNA damage and repair, cell proliferation, differentiation, apoptosis, and senescence. WIP1 promotes the formation and development of tumors as an oncogene and a negative regulator of p53. It is also involved in the regulation of aging, neurological diseases and immune diseases. Recent studies demonstrated the critical roles of WIP1 in the differentiation and function of immune cells including T cells, neutrophils and macrophages. In the present manuscript, we briefly summarized the expression patterns, biological function and the target molecules and signal pathways of WIP1 and mainly discussed the latest advances on the regulatory effects of WIP1 in the immune system. WIP1 may be a potential target molecule to treat cancers and immune diseases such as allergic asthma.
引用
收藏
页码:280 / 291
页数:12
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