Mechanistic Insights into MicroRNA-Mediated Gene Silencing

被引：105
作者：
Duchaine, Thomas F. [1 ,2 ]
Fabian, Marc R. [3 ,4 ]
机构：
[1] McGill Univ, Dept Biochem, Montreal, PQ H3G 1Y6, Canada
[2] McGill Univ, Goodman Canc Res Ctr, Montreal, PQ H3G 1Y6, Canada
[3] McGill Univ, Dept Oncol, Montreal, PQ H3G 1Y6, Canada
[4] Jewish Gen Hosp, Lady Davis Inst, Montreal, PQ H3T 1E2, Canada
来源：
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY | 2019年 / 11卷 / 03期
基金：
加拿大自然科学与工程研究理事会;
关键词：
MESSENGER-RNA DEADENYLATION; POLY(A) BINDING-PROTEIN; TRANSLATIONAL REPRESSION; CRYSTAL-STRUCTURE; STRUCTURAL BASIS; MAMMALIAN MICRORNAS; LET-7; MICRORNA; POLY(A)-BINDING PROTEINS; CAENORHABDITIS-ELEGANS; CCR4-NOT DEADENYLASE;
D O I：
10.1101/cshperspect.a032771
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
MicroRNAs (miRNAs) posttranscriptionally regulate gene expression by repressing protein synthesis and exert a broad influence over development, physiology, adaptation, and disease. Over the past two decades, great strides have been made toward elucidating how miRNAs go about shutting down messenger RNA (mRNA) translation and promoting mRNA decay.
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页数：21
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