Nickel-mediated regio- and chemoselective carboxylation of alkynes in the presence of carbon dioxide

被引：114

作者：

Saito, S ^{[1
]}

Nakagawa, S

Koizumi, T

Hirayama, K

Yamamoto, Y

机构：

[1] Tohoku Univ, Inst Chem React Sci, Sendai, Miyagi 9808578, Japan

[2] Toyama Med & Pharmaceut Univ, Fac Pharmaceut Sci, Toyama 9300194, Japan

[3] Tohoku Univ, Grad Sch Sci, Dept Chem, Sendai, Miyagi 9808578, Japan

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1999年 / 64卷 / 11期

关键词：

D O I：

10.1021/jo982443f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Alkynes are carboxylated in a highly regio- and chemoselective manner in the presence of Ni(cod)(2), DBU, and CO2 to give the carboxylated products in good yields. The reaction was carried out under very mild conditions (CO2 1 atm, 0 degrees C) in the presence of a stoichiometric amount of alkynes, conjugated enynes, or diynes. The high selectivity observed in the reaction would be explained in terms of the stability and the reactivity of the intermediates.

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页码：3975 / 3978

页数：4

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