Nickel-mediated regio- and chemoselective carboxylation of alkynes in the presence of carbon dioxide

被引：114

作者：

Saito, S ^{[1
]}

Nakagawa, S

Koizumi, T

Hirayama, K

Yamamoto, Y

机构：

[1] Tohoku Univ, Inst Chem React Sci, Sendai, Miyagi 9808578, Japan

[2] Toyama Med & Pharmaceut Univ, Fac Pharmaceut Sci, Toyama 9300194, Japan

[3] Tohoku Univ, Grad Sch Sci, Dept Chem, Sendai, Miyagi 9808578, Japan

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1999年 / 64卷 / 11期

关键词：

D O I：

10.1021/jo982443f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Alkynes are carboxylated in a highly regio- and chemoselective manner in the presence of Ni(cod)(2), DBU, and CO2 to give the carboxylated products in good yields. The reaction was carried out under very mild conditions (CO2 1 atm, 0 degrees C) in the presence of a stoichiometric amount of alkynes, conjugated enynes, or diynes. The high selectivity observed in the reaction would be explained in terms of the stability and the reactivity of the intermediates.

引用

页码：3975 / 3978

页数：4

共 31 条

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