Primary antiphospholipid syndrome in monozygotic twins

被引:7
|
作者
Ravindran, V. [1 ]
Rajendran, S. [2 ]
Elias, G. [3 ]
机构
[1] MES Med Coll, Dept Rheumatol, Perinthalmanna, Kerala, India
[2] MES Med Coll, Dept Vasc Surg, Perinthalmanna, Kerala, India
[3] PVS Hosp, Dept Internal Med, Kozhikode, India
关键词
LUPUS ANTICOAGULANT; ANTICARDIOLIPIN ANTIBODIES; THROMBOSIS; CRITERIA; DISEASE; UPDATE; FAMILY;
D O I
10.1177/0961203312467393
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Monozygotic twins, 27 years old, with primary anti-phospholipid syndrome have been described. The first of the twins had obstetric morbidities (one miscarriage at 12 weeks and premature birth of a growth-restricted fetus at 27 weeks secondary to pre-eclampsia) and the second had venous thrombosis. Lupus anticoagulant was present in both and anti-cardiolipin antibodies were present in high titres when re-tested at appropriate intervals. Development of clinical features of APS in monozygotic twins points to an underlying genetic basis in the pathogenesis of anti-phospholipid syndrome. Lupus (2013) 22, 92-94.
引用
收藏
页码:92 / 94
页数:3
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