Brd4 Shields Chromatin from ATM Kinase Signaling Storms

被引：11

作者：

Choi, Serah ^{[1
,2
]}

Bakkenist, Christopher J. ^{[2
,3
]}

机构：

[1] Univ Pittsburgh, Sch Med, Hillman Canc Ctr, UPMC Med Educ Transit Year Residency Program, Pittsburgh, PA 15213 USA

[2] Univ Pittsburgh, Sch Med, Hillman Canc Ctr, Dept Radiat Oncol, Pittsburgh, PA 15213 USA

[3] Univ Pittsburgh, Sch Med, Hillman Canc Ctr, Dept Pharmacol & Chem Biol, Pittsburgh, PA 15213 USA

来源：

SCIENCE SIGNALING | 2013年 / 6卷 / 293期

关键词：

ACTIVATES ATM; DNA; ACETYLATION; COMPLEX;

D O I：

10.1126/scisignal.2004622

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Upon activation, ataxia telangiectasia mutated (ATM) kinase rapidly phosphorylates hundreds of proteins, setting off chaotic signaling storms from areas of damaged chromatin. Recent work by Kaidi and Jackson and Floyd et al. advance our knowledge of the mechanisms that initiate or limit ATM kinase signaling storms at chromatin.

引用

页数：2

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