In vivo degradation and tissue compatibility of ZK60 magnesium alloy with micro-arc oxidation coating in a transcortical model

被引:56
作者
Lin, Xiao [1 ]
Tan, Lili [1 ]
Wang, Qiang [2 ]
Zhang, Guangdao [2 ]
Zhang, Bingchun [1 ]
Yang, Ke [1 ]
机构
[1] Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China
[2] China Med Univ, Sch Stomatol, Shenyang 110002, Peoples R China
来源
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2013年 / 33卷 / 07期
关键词
Magnesium alloy; ZK60; Micro-arc oxidation; Degradation; In vivo; CALCIUM-PHOSPHATE COATINGS; OSTEOCLASTIC RESORPTION; VITRO DEGRADATION; CORROSION BEHAVIOR; BONE RESPONSE; IMPLANTS; BIOCOMPATIBILITY; ZIRCONIUM; SILICATE; BIOLOGY;
D O I
10.1016/j.msec.2013.05.023
中图分类号
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号
0805 ; 080501 ; 080502 ;
摘要
Magnesium alloys were studied extensively as a class of biodegradable metallic materials for medical applications. In the present study, ZK60 magnesium alloy was considered as a candidate and the micro-arc oxidation (MAO) treatment was adopted in order to reduce the degradation rate of the alloy. The in vivo degradation behaviors and biological compatibilities of ZK60 alloys with and without MAO treatment were studied with a transcortical model in rabbits. The implant and the surrounding bone tissues were characterized by CT, SEM and histological methods at 2,4 and 12 weeks after the implantation. The results demonstrated that both the bare and MAO-coated ZK60 alloys completely degraded within 12 weeks in this animal model. The MAO coating decreased the degradation rate of ZK60 alloy and enhanced the response of the surrounding tissues within the first 2 weeks. After then, an acceleration of the degradation of the MAO-coated ZK60 alloy was observed. It was found that the alloy could be degraded before the complete degradation of the MAO coating, leading to the local peeling off of the coating. An in vivo degradation mechanism of the MAO-coated ZK60 alloy was proposed based on the experimental results. The severe localized degradation caused by the peeling off of the MAO coating was the main reason for the acceleration of the degradation of the MAO-coated ZK60 alloy. (C) 2013 Elsevier B.V. All rights reserved.
引用
收藏
页码:3881 / 3888
页数:8
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