Involvements of mu- and kappa-opioid receptors in morphine-induced antinociception in the nucleus accumbens of rats

被引：15

作者：

Xiong, Wei

Yu, Long-Chuan ^{[1
]}

机构：

[1] Peking Univ, Coll Life Sci, Neurobiol Lab, Beijing 100871, Peoples R China

[2] Peking Univ, Coll Life Sci, Natl Lab Biomembrane & Membrane Biotechnol, Beijing 100871, Peoples R China

来源：

NEUROSCIENCE LETTERS | 2006年 / 399卷 / 1-2期

基金：

中国国家自然科学基金;

关键词：

antinociception; nucleus accumbens; morphine; opioid receptor; hindpaw withdrawal latency;

D O I：

10.1016/j.neulet.2006.01.052

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

It is well known that there are three types of opioid receptors, mu- (MOR), delta- (DOR), and kappa-opioid receptor (KOR) in the central nervous system. The present study investigated the involvement of opioid receptors in morphine-induced antinociception in the nucleus accumbens (NAc) of rats. The hindpaw withdrawal latencies to thermal and mechanical stimulation increased markedly after intra-NAc administration of morphine. The antinociceptive effects induced by morphine were dose-dependently inhibited by intra-NAc administration of the non-selective opioid receptor antagonist naloxone. Furthermore, the morphine-induced antinociception was significantly attenuated by subsequent intra-NAc injection of the MOR antagonist beta-funaltrexamine or the KOR antagonist nor-binaltorphimine, but not the DOR antagonist naltrindole. The results indicate that MOR and KOR, but not DOR are involved in the morphine-induced antinociception in the NAc of rats. (c) 2006 Elsevier Ireland Ltd. All rights reserved.

引用

页码：167 / 170

页数：4

共 19 条

[1] Tachykinin NK-1 and NK-3 selective agonists induce analgesia in the formalin test for tonic pain following intra-VTA or intra-accumbens microinfusions [J].