The pharmacological treatment of depression in adults with epilepsy

被引：5

作者：

Mula, Marco ^{[2
]}

Schmitz, Bettina ^{[3
]}

Sander, Josemir W. ^{[1
,4
]}

机构：

[1] UCL Inst Neurol, Dept Clin & Expt Epilepsy, London WC1N 3BG, England

[2] Amedeo Avogadro Univ, Dept Clin & Expt Med, Neurol Sect, Novara, Italy

[3] Charite, Seizure Clin, Dept Neurol, D-13353 Berlin, Germany

[4] SEIN Epilepsy Inst Netherlands Fdn, Heemstede, Netherlands

来源：

EXPERT OPINION ON PHARMACOTHERAPY | 2008年 / 9卷 / 18期

关键词：

antidepressant drugs; antiepileptic drugs; depression; epilepsy; seizures;

D O I：

10.1517/14656560802587024

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Background: Comorbid mood disorders may affect quality of life in people with epilepsy. Objective: To review available data on the use of antidepressant drugs in epilepsy taking into account major concerns that may be encountered by clinicians, namely pharmacokinetic interactions with antiepileptic medications and seizure aggravation. Results: Data on pharmacotherapy of depression in epilepsy are limited with no controlled clinical trials investigating efficacy and safety of antidepressants. Data on seizure risk come from psychiatric samples, thus limiting the general applicability to people with epilepsy. Conclusions: Antidepressant drug doses need to be used and adjusted according to individual clinical needs. Within the therapeutic range, the incidence of seizures in psychiatric populations is low for most antidepressants.

引用

页码：3159 / 3168

页数：10

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