Synthesis and QSAR modeling of 2-acetyl-2-ethoxycarbonyl-1-[4(4′-arylazo)-phenyl]-N,N-dimethylaminophenyl aziridines as potential antibacterial agents

被引：29

作者：

Sharma, Pratibha ^{[1
]}

Kumar, Ashok ^{[1
]}

Upadhyay, Siya ^{[1
]}

Sahu, Vinita ^{[1
]}

Singh, Jitendra ^{[1
]}

机构：

[1] Devi Ahilya Univ, Sch Chem Sci, Indore 452001, Madhya Pradesh, India

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2009年 / 44卷 / 01期

关键词：

Quantitative structure-activity relationship (QSAR); 2-Acetyl-2-ethoxycarbonyl-1-[4(4; '-arylazo)-phenyl]-N; N-dimethylaminophenyl aziridines; Antibacterial; Molar refractivity;

D O I：

10.1016/j.ejmech.2008.02.016

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The present communication deals with the synthesis of a series of 2-acetyl-2-ethoxycarbonyl-1-[4(4'-arylazo)-phenyl]-N,N-dimethylaminophenyl aziridines. The compounds were synthesized in excellent yields (70-80%) and the structures were established on the basis of consistent IR, H-1 NMR and elemental analysis data. The purity has been ascertained by chromatographic resolution using acetic acid-toluene (6:4 v/v) as binary eluent. All the compounds have been tested for their antimicrobial activity against a representative panel of bacteria i.e. Bacillus subtilis, Escherichia coli, Pseudomonas diminuta and Staphylococcus aureus using azinomycin as reference drug. All the synthesized compounds were found to exhibit profound antimicrobial activity. (C) 2008 Elsevier Masson SAS. All rights reserved.

引用

页码：251 / 259

页数：9

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