LONG-TERM TENS TREATMENT DECREASES CORTICAL MOTOR REPRESENTATION IN MULTIPLE SCLEROSIS

被引：9

作者：

Cuypers, K. ^{[1
,2
,3
]}

Leenus, D. J. F. ^{[1
,2
]}

van den Berg, F. E. ^{[3
]}

Levin, O. ^{[3
]}

Thijs, H. ^{[2
,4
,5
]}

Swinnen, S. P. ^{[3
]}

Meesen, R. L. J. ^{[1
,2
,3
]}

机构：

[1] Hasselt Univ, Biomed Res Inst, BIOMED, B-3590 Diepenbeek, Belgium

[2] Hasselt Univ, REVAL Res Inst, B-3590 Diepenbeek, Belgium

[3] Katholieke Univ Leuven, Grp Biomed Sci, Movement Control & Neuroplast Res Grp, Motor Control Lab, B-3001 Heverlee, Belgium

[4] Hasselt Univ, Interuniv Inst Biostat & Stat Bioinformat, I BioStat, B-3590 Diepenbeek, Belgium

[5] Univ Louvain, Interuniv Inst Biostat & Stat Bioinformat, I BioStat, Louvain, Belgium

来源：

NEUROSCIENCE | 2013年 / 250卷

关键词：

cortical motor representation; multiple sclerosis; neural plasticity; TENS; TMS; ELECTRICAL NERVE-STIMULATION; ADAPTIVE FUNCTIONAL-CHANGES; CORTEX EXCITABILITY; CEREBRAL-CORTEX; H-REFLEX; BRAIN; SPASTICITY; DAMAGE; REORGANIZATION; PERFORMANCE;

D O I：

10.1016/j.neuroscience.2013.06.046

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

This study investigated the effects of a long-term transcutaneous electrical nerve stimulation (TENS) treatment on cortical motor representation in patients with multiple sclerosis (MS). In this double-blind crossover design, patients received either TENS or sham stimulation for 3 weeks (1 h per day) on the median nerve region of the most impaired hand, followed by the other stimulation condition after a washout period of 6 months. Cortical motor representation was mapped using transcranial magnetic stimulation (TMS) at the baseline and after the 3-week stimulation protocol. Our results revealed that 3 weeks of daily stimulation with TENS significantly decreased the cortical motor representation of the stimulated muscle in MS patients. Although the mechanisms underlying this decrease remain unclear, our findings indicate that TENS has the ability to induce long-term reorganization in the motor cortex of MS patients. (c) 2013 IBRO. Published by Elsevier Ltd. All rights reserved.

引用

页码：1 / 7

页数：7

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